Rethinking intellectual disability from neuro- to astro-pathology

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• dc.contributor.author Fernández-Blanco, Álvaro
• dc.contributor.author Dierssen, Mara
• dc.date.accessioned 2021-03-18T09:17:25Z
• dc.date.available 2021-03-18T09:17:25Z
• dc.date.issued 2020
• dc.description.abstract Neurodevelopmental disorders arise from genetic and/or from environmental factors and are characterized by different degrees of intellectual disability. The mechanisms that govern important processes sustaining learning and memory, which are severely affected in intellectual disability, have classically been thought to be exclusively under neuronal control. However, this vision has recently evolved into a more integrative conception in which astroglia, rather than just acting as metabolic supply and structural anchoring for neurons, interact at distinct levels modulating neuronal communication and possibly also cognitive processes. Recently, genetic tools have made it possible to specifically manipulate astrocyte activity unraveling novel functions that involve astrocytes in memory function in the healthy brain. However, astrocyte manipulation has also underscored potential mechanisms by which dysfunctional astrocytes could contribute to memory deficits in several neurodevelopmental disorders revealing new pathogenic mechanisms in intellectual disability. Here, we review the current knowledge about astrocyte dysfunction that might contribute to learning and memory impairment in neurodevelopmental disorders, with special focus on Fragile X syndrome and Down syndrome.
• dc.description.sponsorship Funding: The lab of MD is supported by the CRG Severo Ochoa excellence grant, the CIBER of Rare Diseases and Secretaria d’Universitats i Recerca del Departament d’Economia I Coneixement de la Generalitat de Catalunya (Grups consolidats 2017 SGR 926). We also acknowledge the support of the Agencia Estatal de Investigación (PID2019-110755RB-I00/AEI/10.13039/501100011033), H2020 SC1 Gene overdosage and comorbidities during the early lifetime in Down Syndrome GO-DS21- 848077, Jerôme Lejeune Foundation, NIH (Grant Number: 1R01EB 028159-01), Marató TV3, JPND Heroes project, and the Spanish Ministry of Science and Innovation (MICINN) to the EMBL partnership, the Centro de Excelencia Severo Ochoa, and the CERCA Programme/Generalitat de Catalunya
• dc.format.mimetype application/pdf
• dc.identifier.citation Fernández-Blanco A, Dierssen M. Rethinking intellectual disability from neuro- to astro-pathology. Int J Mol Sci. 2020 Nov 27; 21(23): 9039. DOI: 10.3390/ijms21239039
• dc.identifier.doi http://dx.doi.org/10.3390/ijms21239039
• dc.identifier.issn 1422-0067
• dc.identifier.uri http://hdl.handle.net/10230/46837
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof International Journal of Molecular Sciences. 2020 Nov 27;21(23):9039
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/848077
• dc.rights © 2020 by Álvaro Fernández-Blanco and Mara Dierssen. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.other Deficiència mental
• dc.subject.other Down, Síndrome de
• dc.title Rethinking intellectual disability from neuro- to astro-pathology
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion