Early-childhood BMI trajectories in relation to preclinical cardiovascular measurements in adolescence

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• dc.contributor.author Montazeri, Parisa, 1988-
• dc.contributor.author Fossati, Serena
• dc.contributor.author Clemente Batalha Pardal, Diana, 1990-
• dc.contributor.author Cirugeda, Lourdes
• dc.contributor.author Elosua Llanos, Roberto
• dc.contributor.author Fernández-Barrés, Sílvia
• dc.contributor.author Fochs, Silvia
• dc.contributor.author Garcia-Esteban, Raquel
• dc.contributor.author Márquez, Sandra
• dc.contributor.author Pey, Núria
• dc.contributor.author Nawrot, Tim S.
• dc.contributor.author Vrijheid, Martine
• dc.date.accessioned 2023-10-20T06:06:47Z
• dc.date.available 2023-10-20T06:06:47Z
• dc.date.issued 2022
• dc.description.abstract Cardiovascular diseases are the leading causes of morbidity and mortality. Overweight, obesity, and accelerated growth during early childhood have been associated with adverse cardiovascular outcomes in later life. Few studies have assessed whether trajectories of accelerated growth in early childhood are associated with preclinical cardiovascular measurements. We aimed to evaluate the associations between childhood body mass index (BMI) growth trajectories and measures of macro- and microvascular function in early adolescence. Measurements of macrovascular function (systolic and diastolic blood pressure (SBP and DBP), pulse wave velocity (PWV), and microvascular function (central retinal arteriolar/veinular equivalent) were assessed at 11 years old in a Spanish birth cohort study (n = 489). BMI trajectories from birth to 9 years were identified using latent class growth analysis. Multiple linear regression assessed the associations between the BMI trajectories and macro- and microvascular function. Compared to children with average birth size and slower BMI gain (reference), children with a lower birth size and accelerated BMI gain had increased SBP [β = 6.57; (95% CI 4.00, 9.15)], DBP [β = 3.65; (95% CI 1.45, 5.86)], and PWV [β = 0.14; (95% CI 0.01, 0.27)]. Children with higher birth size and accelerated BMI gain had increased SBP [β = 4.75; (95% CI 1.79, 7.71) compared to the reference. No significant associations between BMI trajectories and the microvascular measurements were observed. In conclusion, we found that childhood BMI trajectories characterized by accelerated growth are associated with preclinical macrovascular measurements in young adolescents.
• dc.description.sponsorship The Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds; PI12/01890 incl. FEDER funds; CP13/00054 incl. FEDER funds; PI15/00118 incl. FEDER funds; CP16/00128 incl. FEDER funds; PI16/00118 incl. FEDER funds; PI16/00261 incl. FEDER funds; PI18/00547 incl. FEDER funds), CIBERESP, Generalitat de Catalunya-CIRIT 1999SGR 00241, Generalitat de Catalunya-AGAUR (2009 SGR 501, 2014 SGR 822), Fundació La marató de TV3 (090430), Spanish Ministry of Economy and Competitiveness (SAF2012-32991 incl. FEDER funds), Agence Nationale de Securite Sanitaire de l’Alimentation de l’Environnement et du Travail (1262C0010; EST-2016 RF-21), EU Commission (261357, 308333, 603794 and 634453).
• dc.format.mimetype application/pdf
• dc.identifier.citation Montazeri P, Fossati S, Clemente DBP, Cirugeda L, Elosua R, Fernández-Barrés S, Fochs S, Garcia-Esteban R, Marquez S, Pey N, Nawrot TS, Vrijheid M. Early-childhood BMI trajectories in relation to preclinical cardiovascular measurements in adolescence. J Dev Orig Health Dis. 2022 Jun;13(3):322-9. DOI: 10.1017/S2040174421000441
• dc.identifier.doi http://doi.org/10.1017/S2040174421000441
• dc.identifier.issn 2040-1744
• dc.identifier.uri http://hdl.handle.net/10230/58102
• dc.language.iso eng
• dc.publisher Cambridge University Press
• dc.relation.ispartof J Dev Orig Health Dis. 2022 Jun;13(3):322-9
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012-32991
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/603794
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/634453
• dc.rights This article has been published in a revised form in Journal of developmental origins of health and disease [http://doi.org/10.1017/S2040174421000441]. This version is published under a Creative Commons CC-BY-NC-ND licence. No commercial re-distribution or re-use allowed. Derivative works cannot be distributed. © The Author(s), 2021. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Growth
• dc.subject.keyword Blood pressure
• dc.subject.keyword Body mass index (BMI)
• dc.subject.keyword Cardiovascular health
• dc.subject.keyword Growth trajectories
• dc.title Early-childhood BMI trajectories in relation to preclinical cardiovascular measurements in adolescence
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion