Polybrominated diphenyl ethers (PBDEs) in breast milk and neuropsychological development in infants

Gascon Merlos, Mireia, 1984-; Fort, Marta; Martínez, David; Carsin, Anne-Elie; Forns i Guzman, Joan, 1981-; Grimalt Obrador, Joan; Santa Marina, Loreto; Lertxundi, Nerea; Sunyer Deu, Jordi; Vrijheid, Martine

Polybrominated diphenyl ethers (PBDEs) in breast milk and neuropsychological development in infants

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dc.contributor.author Gascon Merlos, Mireia, 1984-ca
dc.contributor.author Fort, Martaca
dc.contributor.author Martínez, Davidca
dc.contributor.author Carsin, Anne-Elieca
dc.contributor.author Forns i Guzman, Joan, 1981-ca
dc.contributor.author Grimalt Obrador, Joanca
dc.contributor.author Santa Marina, Loretoca
dc.contributor.author Lertxundi, Nereaca
dc.contributor.author Sunyer Deu, Jordica
dc.contributor.author Vrijheid, Martineca
dc.date.accessioned 2015-04-09T08:14:44Z
dc.date.available 2015-04-09T08:14:44Z
dc.date.issued 2012ca
dc.description.abstract Background: There is increasing interest in the potential effects of polybrominated diphenyl ethers (PBDEs) on children’s neuropsychological development, but only a few small studies have evaluated such effects. Objectives: Our goal was to examine the association between PBDE concentrations in colostrum and infant neuropsychological development and to assess the influence of other persistent organic pollutants (POPs) on such association. Methods: We measured concentrations of PBDEs and other POPs in colostrum samples of 290 women recruited in a Spanish birth cohort. We tested children for mental and psychomotor development with the Bayley Scales of Infant Development at 12–18 months of age. We analyzed the sum of the seven most common PBDE congeners (BDEs 47, 99, 100, 153, 154, 183, 209) and each congener separately. Results: Increasing Σ7PBDEs concentrations showed an association of borderline statistical significance with decreasing mental development scores (β per log ng/g lipid = –2.25; 95% CI: –4.75, 0.26). BDE-209, the congener present in highest concentrations, appeared to be the main congener responsible for this association (β = –2.40, 95% CI: –4.79, –0.01). There was little evidence for an association with psychomotor development. After adjustment for other POPs, the BDE-209 association with mental development score became slightly weaker (β = –2.10, 95% CI: –4.66, 0.46). Conclusions: Our findings suggest an association between increasing PBDE concentrations in colostrum and a worse infant mental development, particularly for BDE-209, but require confirmation in larger studies. The association, if causal, may be due to unmeasured BDE-209 metabolites, including OH-PBDEs (hydroxylated PBDEs), which are more toxic, more stable, and more likely to cross the placenta and to easily reach the brain than BDE-209.en
dc.description.sponsorship This study was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041, FIS-PI06/0867, and FIS-PS09/00090), Spanish Ministry of Health (FIS-PI041436 and FIS- PI081151), Generalitat de Catalunya-CIRIT (1999SGR 00241), Department of Health of the Basque Government (2005111093 and 2009111069), the Provincial Government of Gipuzkoa (DFG06/004 and DFG08/001), and Fundación Roger Tornéen
dc.format.mimetype application/pdfca
dc.identifier.citation Gascon M, Fort M, Martinez D, Carsin AE, Forns J, Grimalt JO et al. Polybrominated diphenyl ethers (PBDEs) in breast milk and neuropsychological development in infants. Environ Health Perspect. 2012;120(12):1760-5. DOI: 10.1289/ehp.1205266ca
dc.identifier.doi http://dx.doi.org/10.1289/ehp.1205266
dc.identifier.issn 0091-6765ca
dc.identifier.uri http://hdl.handle.net/10230/23370
dc.language.iso engca
dc.publisher National Institute of Environmental Health Sciences (NIEHS)ca
dc.relation.ispartof Environmental Health Perspectives. 2012;120(12):1760-5
dc.rights Reproduced with permission from Environmental Health Perspectivesca
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.subject.keyword Childrenen
dc.subject.keyword Environmentalen
dc.subject.keyword Neurodevelopmenten
dc.subject.keyword Persistent organic pollutants (POPs)en
dc.subject.keyword Polybrominated diphenyl ethers (PBDEs)en
dc.subject.other Malalties immunològiques en els infantsca
dc.subject.other Infants -- Creixementen
dc.title Polybrominated diphenyl ethers (PBDEs) in breast milk and neuropsychological development in infantsen
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

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