Gene duplications, divergence and recombination shape adaptive evolution of the fish ectoparasite Gyrodactylus bullatarudis

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• dc.contributor.author Konczal, Mateusz
• dc.contributor.author Przesmycka, Karolina J.
• dc.contributor.author Mohammed, Ryan S.
• dc.contributor.author Phillips, Karl P.
• dc.contributor.author Cámara, Francisco
• dc.contributor.author Chmielewski, Sebastian
• dc.contributor.author Hahn, Christoph
• dc.contributor.author Guigó Serra, Roderic
• dc.contributor.author Cable, Jo
• dc.contributor.author Radwan, Jacek
• dc.date.accessioned 2023-10-05T06:06:35Z
• dc.date.available 2023-10-05T06:06:35Z
• dc.date.issued 2020
• dc.description.abstract Determining the molecular basis of parasite adaptation to its host is an important component in understanding host-parasite coevolution and the epidemiology of parasitic infections. Here, we investigate short- and long-term adaptive evolution in the eukaryotic parasite Gyrodactylus bullatarudis infecting Caribbean guppies (Poecilia reticulata), by comparing the reference genome of Tobagonian G. bullatarudis with other Platyhelminthes, and by analysing resequenced samples from local Trinidadian populations. At the macroevolutionary timescale, we observed duplication of G-protein and serine proteases genes, which are probably important in host-parasite arms races. Serine protease also showed strong evidence of ongoing, diversifying selection at the microevolutionary timescale. Furthermore, our analyses revealed that a hybridization event, involving two divergent genomes, followed by recombination has dramatically affected the genetic composition of Trinidadian populations. The recombinant genotypes invaded Trinidad and replaced local parasites in all populations. We localized more than 300 genes in regions fixed in local populations for variants of different origin, possibly due to diversifying selection pressure from local host populations. In addition, around 70 genes were localized in regions identified as heterozygous in some, but not all, individuals. This pattern is consistent with a very recent spread of recombinant parasites. Overall, our results are consistent with the idea that recombination between divergent genomes can result in particularly successful parasites.
• dc.format.mimetype application/pdf
• dc.identifier.citation Konczal M, Przesmycka KJ, Mohammed RS, Phillips KP, Camara F, Chmielewski S, Hahn C, Guigo R, Cable J, Radwan J. Gene duplications, divergence and recombination shape adaptive evolution of the fish ectoparasite Gyrodactylus bullatarudis. Mol Ecol. 2020; 29(8):1494-507. DOI: 10.1111/mec.15421
• dc.identifier.doi http://dx.doi.org/10.1111/mec.15421
• dc.identifier.issn 0962-1083
• dc.identifier.uri http://hdl.handle.net/10230/58042
• dc.language.iso eng
• dc.publisher Wiley-Blackwell
• dc.relation.ispartof Mol Ecol. 2020; 29(8):1494-507
• dc.rights This is the pre-peer reviewed version of the following article: Konczal M, Przesmycka KJ, Mohammed RS, Phillips KP, Camara F, Chmielewski S, Hahn C, Guigo R, Cable J, Radwan J. Gene duplications, divergence and recombination shape adaptive evolution of the fish ectoparasite Gyrodactylus bullatarudis. Mol Ecol. 2020; 29(8):1494-507. DOI: 10.1111/mec.15421, which has been published in final form at http://dx.doi.org/10.1111/mec.15421. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Adaptive evolution
• dc.subject.keyword Admixture
• dc.subject.keyword Hybrids
• dc.subject.keyword Parasite
• dc.subject.keyword Recombination
• dc.subject.keyword Reference genome
• dc.title Gene duplications, divergence and recombination shape adaptive evolution of the fish ectoparasite Gyrodactylus bullatarudis
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion