The pathogenesis of chronic spontaneous urticaria: the role of infiltrating cells
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- dc.contributor.author Giménez Arnau, Anna Maria
- dc.contributor.author DeMontojoye, Laurence
- dc.contributor.author Asero, Riccardo
- dc.contributor.author Cugno, Massimo
- dc.contributor.author Kulthanan, Kanokvalai
- dc.contributor.author Yanase, Yuhki
- dc.contributor.author Hide, Michihiro
- dc.contributor.author Kaplan, Allen P.
- dc.date.accessioned 2021-11-29T07:33:30Z
- dc.date.issued 2021
- dc.description.abstract Chronic spontaneous urticaria is characterized by a perivascular non-necrotizing cellular infiltrate around small venules of the skin. It consists primarily of CD4(+) lymphocytes, a prominence of the T helper (Th)2 subtype but also Th1 cells, with Th17 cell-derived cytokines elevated in plasma. There are also neutrophils, eosinophils, basophils, and monocytes. Chemokines derived from mast cells and activated endothelial cells drive the process. Although the role of the cellular infiltrate has not previously been addressed, each constituent can contribute to the overall pathogenesis. It is of interest that CSU responds to corticosteroid, yet, short-term steroids do not affect autoimmunity or degranulation of mast cells, and act on margination of cells along the endothelium and chemotaxis to enter the surrounding dermis. In this review, we address each cell's contribution to the overall inflammatory response, as it is currently understood, with a view toward development of therapeutic options that impede the function of critical cells and/or their secretory products.
- dc.format.mimetype application/pdf
- dc.identifier.citation Giménez-Arnau AM, DeMontojoye L, Asero R, Cugno M, Kulthanan K, Yanase Y, Hide M, Kaplan AP. The pathogenesis of chronic spontaneous urticaria: the role of infiltrating cells. J Allergy Clin Immunol Pract. 2021;9(6):2195-208. DOI: 10.1016/j.jaip.2021.03.033
- dc.identifier.doi http://dx.doi.org/10.1016/j.jaip.2021.03.033
- dc.identifier.issn 2213-2198
- dc.identifier.uri http://hdl.handle.net/10230/49080
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof J Allergy Clin Immunol Pract. 2021;9(6):2195-208
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.jaip.2021.03.033
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Basophil
- dc.subject.keyword Endothelial cell
- dc.subject.keyword Eosinophil
- dc.subject.keyword Lymphocyte
- dc.subject.keyword Neuroinflammation
- dc.title The pathogenesis of chronic spontaneous urticaria: the role of infiltrating cells
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion