Role of leptin in the association between body adiposity and persistent asthma: a longitudinal study
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- dc.contributor.author Li, Zhen
- dc.contributor.author Leynaert, Bénédicte
- dc.contributor.author Dumas, Orianne
- dc.contributor.author Díaz Gil, Oscar
- dc.contributor.author García Aymerich, Judith
- dc.contributor.author Fitó Colomer, Montserrat
- dc.contributor.author Le Moual, Nicole
- dc.contributor.author Pison, Christophe
- dc.contributor.author Romieu, Isabelle
- dc.contributor.author Siroux, Valérie
- dc.contributor.author Camargo, Carlos A.
- dc.contributor.author Varraso, Raphaëlle
- dc.contributor.author Nadif, Rachel
- dc.date.accessioned 2020-03-23T07:36:24Z
- dc.date.issued 2019
- dc.description.abstract Objective: Obesity is a likely risk factor for asthma. However, underlying mechanisms by which obesity affects asthma activity remain poorly understood. This study aimed to investigate the role of leptin, an adipocyte-derived proinflammatory protein, as a mediator in the association between body adiposity (assessed using BMI, waist circumference, and body fat percentage) and persistent asthma. Methods: A causal approach to mediation analysis was used to disentangle total and direct effects and the indirect effect mediated by leptin, using data from the French prospective French Epidemiological Study on the Genetics and Environment of Asthma (EGEA) (baseline: 2003-2007; follow-up: 2011-2013; mean follow-up time: 7 years). A total of 331 participants with current asthma at baseline were included. Results: Per 1-SD increment in BMI, waist circumference, and body fat percentage, the adjusted odds ratios of the total effect were 1.59 (95% CI: 0.95-2.97), 2.06 (1.06-4.00), and 3.25 (1.01-9.41), respectively; the odds ratios of the indirect effect mediated by leptin were 1.68 (1.09-2.46), 1.55 (0.99-2.57), and 1.99 (0.94-4.83), respectively. Conclusions: Leptin partly (> 60%) mediated the association between high body adiposity and persistent asthma over time. Using a newly developed analytic approach, this longitudinal study brought new insight into one mechanism by which obesity may affect asthma activity.
- dc.format.mimetype application/pdf
- dc.identifier.citation Li Z, Leynaert B, Dumas O, Diaz Gil O, Garcia-Aymerich J, Fito Colomer M, Le Moual N, Pison C, Romieu I, Siroux V, Camargo CA Jr, Varraso R, Nadif R. Role of leptin in the association between body adiposity and persistent asthma: a longitudinal study. Obesity (Silver Spring). 2019; 27(6):894-98. DOI: 10.1002/oby.22466
- dc.identifier.doi http://dx.doi.org/10.1002/oby.22466
- dc.identifier.issn 1930-7381
- dc.identifier.uri http://hdl.handle.net/10230/43980
- dc.language.iso eng
- dc.publisher Wiley
- dc.relation.ispartof Obesity (Silver Spring). 2019;27(6):894-98
- dc.rights This is the peer reviewed version of the following article: Li Z, Leynaert B, Dumas O, Diaz Gil O, Garcia-Aymerich J, Fito Colomer M, Le Moual N, Pison C, Romieu I, Siroux V, Camargo CA Jr, Varraso R, Nadif R. Role of leptin in the association between body adiposity and persistent asthma: a longitudinal study. Obesity (Silver Spring). 2019; 27(6):894-98. DOI: 10.1002/oby.22466, which has been published in final form at http://dx.doi.org/10.1002/oby.22466. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.other Obesitat
- dc.subject.other Asma
- dc.title Role of leptin in the association between body adiposity and persistent asthma: a longitudinal study
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion