Mortality and biochemical recurrence after surgery, brachytherapy, or external radiotherapy for localized prostate cancer: a 10-year follow-up cohort study

Mostra el registre complet Registre parcial de l'ítem

  • dc.contributor.author Suárez Novo, José Francisco
  • dc.contributor.author Zamora, Víctor
  • dc.contributor.author Garin Boronat, Olatz, 1979-
  • dc.contributor.author Gutiérrez, Cristina
  • dc.contributor.author Pont Acuña, Àngels
  • dc.contributor.author Pardo Cladellas, Yolanda
  • dc.contributor.author Goñi, Alai
  • dc.contributor.author Mariño, Alfonso
  • dc.contributor.author Hervás, Asunción
  • dc.contributor.author Herruzo, Ismael
  • dc.contributor.author Cabrera Roldán, Patricia
  • dc.contributor.author Sancho-Pardo, Gemma
  • dc.contributor.author Ponce de León, Javier
  • dc.contributor.author Macías, Víctor
  • dc.contributor.author Guedea, Ferrán
  • dc.contributor.author Vigués, Francesc
  • dc.contributor.author Castells, Manuel
  • dc.contributor.author Ferrer Forés, Maria Montserrat
  • dc.contributor.author Multicentric Spanish Group of Clinically Localized Prostate Cancer
  • dc.date.accessioned 2022-09-12T05:50:32Z
  • dc.date.available 2022-09-12T05:50:32Z
  • dc.date.issued 2022
  • dc.description.abstract To compare the effectiveness at ten years of follow-up of radical prostatectomy, brachytherapy and external radiotherapy, in terms of overall survival, prostate cancer-specific mortality and biochemical recurrence. Cohort of men diagnosed with localized prostate cancer (T1/T2 and low/intermediate risk) from ten Spanish hospitals, followed for 10 years. The treatment selection was decided jointly by patients and physicians. Of 704 participants, 192 were treated with open radical retropubic prostatectomy, 317 with 125I brachytherapy alone, and 195 with 3D external beam radiation. We evaluated overall survival, prostate cancer-specific mortality, and biochemical recurrence. Kaplan-Meier estimators were plotted, and Cox proportional-hazards regression models were constructed to estimate hazard ratios (HR), adjusted by propensity scores. Of the 704 participants, 542 patients were alive ten years after treatment, and a total of 13 patients have been lost during follow-up. After adjusting by propensity score and Gleason score, brachytherapy and external radiotherapy were not associated with decreased 10-year overall survival (aHR = 1.36, p = 0.292 and aHR = 1.44, p = 0.222), but presented higher biochemical recurrence (aHR = 1.93, p = 0.004 and aHR = 2.56, p < 0.001) than radical prostatectomy at ten years of follow-up. Higher prostate cancer-specific mortality was also observed in external radiotherapy (aHR = 9.37, p = 0.015). Novel long-term results are provided on the effectiveness of brachytherapy to control localized prostate cancer ten years after treatment, compared to radical prostatectomy and external radiotherapy, presenting high overall survival, similarly to radical prostatectomy, but higher risk of biochemical progression. These findings provide valuable information to facilitate shared clinical decision-making.Study identifier at ClinicalTrials.gov: NCT01492751.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Suárez JF, Zamora V, Garin O, Gutiérrez C, Pont À, Pardo Y, Goñi A, Mariño A, Hervás A, Herruzo I, Cabrera P, Sancho G, Ponce de León J, Macías V, Guedea F, Vigués F, Castells M, Ferrer M; Multicentric Spanish Group of Clinically Localized Prostate Cancer. Mortality and biochemical recurrence after surgery, brachytherapy, or external radiotherapy for localized prostate cancer: a 10-year follow-up cohort study. Sci Rep. 2022 Jul 22;12(1):12589. DOI: 10.1038/s41598-022-16395-w
  • dc.identifier.doi http://dx.doi.org/10.1038/s41598-022-16395-w
  • dc.identifier.issn 2045-2322
  • dc.identifier.uri http://hdl.handle.net/10230/54038
  • dc.language.iso eng
  • dc.publisher Nature Research
  • dc.relation.ispartof Sci Rep. 2022 Jul 22;12(1):12589
  • dc.rights © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Outcomes research
  • dc.subject.keyword Prostate
  • dc.subject.keyword Prostate cancer
  • dc.title Mortality and biochemical recurrence after surgery, brachytherapy, or external radiotherapy for localized prostate cancer: a 10-year follow-up cohort study
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Departament de Medicina i Ciències de la Vida)
Articles (Hospital del Mar Research Institute)