STereotactic Arrhythmia Radioablation (STAR): the standardized treatment and outcome platform for stereotactic therapy of re-entrant tachycardia by a multidisciplinary consortium (STOPSTORM.eu) and review of current patterns of STAR practice in Europe

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  • dc.contributor.author Grehn, Melanie
  • dc.contributor.author Algara López, Manuel-Ignacio
  • dc.contributor.author Martí-Almor, Julio
  • dc.contributor.author Verhoeff, Joost J. C.
  • dc.date.accessioned 2023-09-15T06:19:37Z
  • dc.date.available 2023-09-15T06:19:37Z
  • dc.date.issued 2023
  • dc.description Data de publicació electrònica: 07-04-2023
  • dc.description.abstract The EU Horizon 2020 Framework-funded Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary (STOPSTORM) consortium has been established as a large research network for investigating STereotactic Arrhythmia Radioablation (STAR) for ventricular tachycardia (VT). The aim is to provide a pooled treatment database to evaluate patterns of practice and outcomes of STAR and finally to harmonize STAR within Europe. The consortium comprises 31 clinical and research institutions. The project is divided into nine work packages (WPs): (i) observational cohort; (ii) standardization and harmonization of target delineation; (iii) harmonized prospective cohort; (iv) quality assurance (QA); (v) analysis and evaluation; (vi, ix) ethics and regulations; and (vii, viii) project coordination and dissemination. To provide a review of current clinical STAR practice in Europe, a comprehensive questionnaire was performed at project start. The STOPSTORM Institutions' experience in VT catheter ablation (83% ≥ 20 ann.) and stereotactic body radiotherapy (59% > 200 ann.) was adequate, and 84 STAR treatments were performed until project launch, while 8/22 centres already recruited VT patients in national clinical trials. The majority currently base their target definition on mapping during VT (96%) and/or pace mapping (75%), reduced voltage areas (63%), or late ventricular potentials (75%) during sinus rhythm. The majority currently apply a single-fraction dose of 25 Gy while planning techniques and dose prescription methods vary greatly. The current clinical STAR practice in the STOPSTORM consortium highlights potential areas of optimization and harmonization for substrate mapping, target delineation, motion management, dosimetry, and QA, which will be addressed in the various WPs.
  • dc.description.sponsorship This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 945119.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Grehn M, Mandija S, Miszczyk M, Krug D, Tomasik B, Stickney KE, et al. STereotactic Arrhythmia Radioablation (STAR): the standardized treatment and outcome platform for stereotactic therapy of re-entrant tachycardia by a multidisciplinary consortium (STOPSTORM.eu) and review of current patterns of STAR practice in Europe. Europace. 2023;25(4):1284–95. DOI: 10.1093/europace/euac238
  • dc.identifier.doi http://dx.doi.org/10.1093/europace/euac238
  • dc.identifier.issn 1099-5129
  • dc.identifier.uri http://hdl.handle.net/10230/57867
  • dc.language.iso eng
  • dc.publisher Oxford University Press
  • dc.relation.ispartof Europace. 2023;25(4):1284–95
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/945119
  • dc.rights © The Author(s) 2023. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri https://creativecommons.org/licenses/by-nc/4.0/
  • dc.subject.keyword Cardiac arrhythmias
  • dc.subject.keyword Consortium
  • dc.subject.keyword EU Horizon 2020
  • dc.subject.keyword Stereotactic arrhythmia radioablation
  • dc.subject.keyword Stereotactic body radiotherapy
  • dc.subject.keyword Ventricular tachycardia
  • dc.title STereotactic Arrhythmia Radioablation (STAR): the standardized treatment and outcome platform for stereotactic therapy of re-entrant tachycardia by a multidisciplinary consortium (STOPSTORM.eu) and review of current patterns of STAR practice in Europe
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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