Gathering and exploring scientific knowledge in pharmacovigilance
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- dc.contributor.author Lopes, Pedroca
- dc.contributor.author Nunes, Tiagoca
- dc.contributor.author Campos, Davidca
- dc.contributor.author Furlong, Laura I., 1971-ca
- dc.contributor.author Bauer-Mehren, Annaca
- dc.contributor.author Sanz, Ferranca
- dc.contributor.author Carrascosa Baena, María Carmen, 1972-ca
- dc.contributor.author Mestres i López, Jordica
- dc.contributor.author Kors, Jan A.ca
- dc.contributor.author Singh, Baratca
- dc.contributor.author van Mulligen, Erik M.ca
- dc.contributor.author van der Lei, Johanca
- dc.contributor.author Diallo, Gayoca
- dc.contributor.author Avillach, Paulca
- dc.contributor.author Ahlberg Helgee, Ernstca
- dc.contributor.author Boyer, Scottca
- dc.contributor.author Díaz, Carlosca
- dc.contributor.author Oliveira, José Luisca
- dc.date.accessioned 2015-05-21T10:57:56Z
- dc.date.available 2015-05-21T10:57:56Z
- dc.date.issued 2013ca
- dc.description.abstract Pharmacovigilance plays a key role in the healthcare domain through the assessment, monitoring and discovery of interactions amongst drugs and their effects in the human organism. However, technological advances in this field have been slowing down over the last decade due to miscellaneous legal, ethical and methodological constraints. Pharmaceutical companies started to realize that collaborative and integrative approaches boost current drug research and development processes. Hence, new strategies are required to connect researchers, datasets, biomedical knowledge and analysis algorithms, allowing them to fully exploit the true value behind state-of-the-art pharmacovigilance efforts. This manuscript introduces a new platform directed towards pharmacovigilance knowledge providers. This system, based on a service-oriented architecture, adopts a plugin-based approach to solve fundamental pharmacovigilance software challenges. With the wealth of collected clinical and pharmaceutical data, it is now possible to connect knowledge providers’ analysis and exploration algorithms with real data. As a result, new strategies allow a faster identification of high-risk interactions between marketed drugs and adverse events, and enable the automated uncovering of scientific evidence behind them. With this architecture, the pharmacovigilance field has a new platform to coordinate large-scale drug evaluation efforts in a unique ecosystem, publicly available at http://bioinformatics.ua.pt/euadr/.en
- dc.description.sponsorship This work was supported by the European Commission (EU-ADR, ICT‐215847), FCT (PTDC/EIA‐CCO/100541/2008), and Instituto de Salud Carlos III FEDER (CP10/00524). The Research Programme on Biomedical Informatics (GRIB) is a node of the Spanish National Institute of Bioinformatics (INB)en
- dc.format.mimetype application/pdfca
- dc.identifier.citation Lopes P, Nunes T, Campos D, Furlong LI, Bauer-Mehren A, Sanz F et al. Gathering and exploring scientific knowledge in pharmacovigilance. PLoS ONE. 2013;8(12):e83016. DOI: 10.1371/journal.pone.0083016ca
- dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0083016
- dc.identifier.issn 1932-6203ca
- dc.identifier.uri http://hdl.handle.net/10230/23608
- dc.language.iso engca
- dc.publisher Public Library of Science (PLoS)ca
- dc.relation.ispartof PLoS ONE. 2013;8(12):e83016
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/215847ca
- dc.rights © 2013 Lopes et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits/nunrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Medicamentsca
- dc.subject.other Farmacologiaca
- dc.subject.other Internetca
- dc.title Gathering and exploring scientific knowledge in pharmacovigilanceen
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca