Influence of dietary inulin on fecal microbiota, cardiometabolic risk factors, eicosanoids, and oxidative stress in rats fed a high-fat diet

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• dc.contributor.author Miralles-Pérez, Bernat
• dc.contributor.author Nogués, Maria Rosa
• dc.contributor.author Sánchez-Martos, Vanessa
• dc.contributor.author Fortuño-Mar, Àngels
• dc.contributor.author Ramos-Romero, Sara
• dc.contributor.author Torres, Josep Lluís
• dc.contributor.author Ponomarenko, Julia
• dc.contributor.author Amézqueta, Susana
• dc.contributor.author Zhang, Xiang
• dc.contributor.author Romeu, Marta
• dc.date.accessioned 2023-03-06T07:22:32Z
• dc.date.available 2023-03-06T07:22:32Z
• dc.date.issued 2022
• dc.description.abstract The present study examined the influence of inulin on fecal microbiota, cardiometabolic risk factors, eicosanoids, and oxidative stress in rats on a high-fat (HF) diet. Thirty-six male Wistar-Kyoto rats were divided into three dietary groups: standard diet, HF diet, and HF diet + Inulin diet. After 10 weeks, the HF + Inulin diet promoted high dominance of a few bacterial genera including Blautia and Olsenella in feces while reducing richness, diversity, and rarity compared to the HF diet. These changes in fecal microbiota were accompanied by an increased amount of propionic acid in feces. The HF + Inulin diet decreased cardiometabolic risk factors, decreased the amount of the eicosanoids 11(12)-EET and 15-HETrE in the liver, and decreased oxidative stress in blood compared to the HF diet. In conclusion, increasing consumption of inulin may be a useful nutritional strategy to protect against the onset of obesity and its associated metabolic abnormalities by means of modulation of gut microbiota.
• dc.description.sponsorship This work was supported by the Spanish Ministry of Economy and Competitiveness (grant number: AGL2017-83599-R). J.P. was supported by the MEIC to the EMBL partnership, Centro de Excelencia Severo Ochoa and CERCA Programme/Generalitat de Catalunya.
• dc.format.mimetype application/pdf
• dc.identifier.citation Miralles-Pérez B, Nogués MR, Sánchez-Martos V, Fortuño-Mar À, Ramos-Romero S, Torres JL, Ponomarenko J, Amézqueta S, Zhang X, Romeu M. Influence of dietary inulin on fecal microbiota, cardiometabolic risk factors, eicosanoids, and oxidative stress in rats fed a high-fat diet. Foods. 2022 Dec 16;11(24):4072. DOI: 10.3390/foods11244072
• dc.identifier.doi http://dx.doi.org/10.3390/foods11244072
• dc.identifier.issn 2304-8185
• dc.identifier.uri http://hdl.handle.net/10230/56040
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Foods. 2022 Dec 16;11(24):4072
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/AGL2017-83599-R
• dc.rights © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Dyslipidemia
• dc.subject.keyword Endogenous antioxidants
• dc.subject.keyword Fatty liver
• dc.subject.keyword Glucose intolerance
• dc.subject.keyword Gut microbiota
• dc.subject.keyword Insulin resistance
• dc.subject.keyword Lipid peroxidation
• dc.subject.keyword Obesity
• dc.title Influence of dietary inulin on fecal microbiota, cardiometabolic risk factors, eicosanoids, and oxidative stress in rats fed a high-fat diet
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion