Pharmacological effects of methylone and MDMA in humans

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• dc.contributor.author Poyatos, Lourdes
• dc.contributor.author Pérez Mañá, Clara
• dc.contributor.author Hladun, Olga
• dc.contributor.author Núñez-Montero, Melani
• dc.contributor.author de la Rosa, Georgina
• dc.contributor.author Martín, Soraya
• dc.contributor.author Barriocanal, Ana Maria
• dc.contributor.author Carabias, Lydia
• dc.contributor.author Kelmendi, Benjamin
• dc.contributor.author Taoussi, Omayema
• dc.contributor.author Busardò, Francesco Paolo
• dc.contributor.author Fonseca Casals, Francina
• dc.contributor.author Torrens, Marta
• dc.contributor.author Pichini, Simona
• dc.contributor.author Farré, Magí
• dc.contributor.author Papaseit, Esther
• dc.date.accessioned 2023-06-20T06:15:37Z
• dc.date.available 2023-06-20T06:15:37Z
• dc.date.issued 2023
• dc.description.abstract Methylone is one of the most common synthetic cathinones popularized as a substitute for 3,4-methylenedioxymethamphetamine (MDMA, midomafetamine) owing to its similar effects among users. Both psychostimulants exhibit similar chemistry (i.e., methylone is a β-keto analog of MDMA) and mechanisms of action. Currently, the pharmacology of methylone remains scarcely explored in humans. Herein, we aimed to evaluate the acute pharmacological effects of methylone and its abuse potential in humans when compared with that of MDMA following oral administration under controlled conditions. Seventeen participants of both sexes (14 males, 3 females) with a previous history of psychostimulant use completed a randomized, double-blind, placebo-controlled, crossover clinical trial. Participants received a single oral dose of 200 mg of methylone, 100 mg of MDMA, and a placebo. The variables included physiological effects (blood pressure, heart rate, oral temperature, pupil diameter), subjective effects using visual analog scales (VAS), the short form of the Addiction Research Center Inventory (ARCI), the Evaluation of Subjective Effects of Substances with Abuse Potential questionnaire (VESSPA-SSE), and the Sensitivity to Drug Reinforcement Questionnaire (SDRQ), and psychomotor performance (Maddox wing, psychomotor vigilance task). We observed that methylone could significantly increase blood pressure and heart rate and induce pleasurable effects, such as stimulation, euphoria, wellbeing, enhanced empathy, and altered perception. Methylone exhibited an effect profile similar to MDMA, with a faster overall onset and earlier disappearance of subjective effects. These results suggest that abuse potential of methylone is comparable to that of MDMA in humans.
• dc.format.mimetype application/pdf
• dc.identifier.citation Poyatos L, Pérez-Mañá C, Hladun O, Núñez-Montero M, de la Rosa G, Martín S, et al. Pharmacological effects of methylone and MDMA in humans. Front Pharmacol. 2023 Feb 17;14:1122861. DOI: 10.3389/fphar.2023.1122861
• dc.identifier.doi http://dx.doi.org/10.3389/fphar.2023.1122861
• dc.identifier.issn 1663-9812
• dc.identifier.uri http://hdl.handle.net/10230/57241
• dc.language.iso eng
• dc.publisher Frontiers
• dc.relation.ispartof Frontiers in Pharmacology. 2023 Feb 17;14:1122861
• dc.rights © 2023 Poyatos, Pérez-Mañá, Hladun, Núñez-Montero, de la Rosa, Martín, Barriocanal, Carabias, Kelmendi, Taoussi, Busardò, Fonseca, Torrens, Pichini, Farré and Papaseit. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Methylone
• dc.subject.keyword 3,4-methylenedioxymethcathinone
• dc.subject.keyword MDMA
• dc.subject.keyword 3,4-methylenedioxymethamphetamine
• dc.subject.keyword New psychoactive substances
• dc.subject.keyword Synthetic cathinones
• dc.subject.keyword Bath salts
• dc.subject.keyword Psychostimulants
• dc.title Pharmacological effects of methylone and MDMA in humans
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion