Evolution of cytokine production capacity in ancient and modern European populations

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• dc.contributor.author Domínguez-Andrés, Jorge
• dc.contributor.author Kuijpers, Yunus
• dc.contributor.author Bakker, Olivier B.
• dc.contributor.author Jaeger, Martin
• dc.contributor.author Xu, Cheng-Jian
• dc.contributor.author van der Meer, Jos W.M.
• dc.contributor.author Jakobsson, Mattias
• dc.contributor.author Bertranpetit, Jaume, 1952-
• dc.contributor.author Joosten, Leo Ab
• dc.contributor.author Li, Yang
• dc.contributor.author Netea, Mihai G
• dc.date.accessioned 2021-11-10T07:49:00Z
• dc.date.available 2021-11-10T07:49:00Z
• dc.date.issued 2021
• dc.description.abstract As our ancestors migrated throughout different continents, natural selection increased the presence of alleles advantageous in the new environments. Heritable variations that alter the susceptibility to diseases vary with the historical period, the virulence of the infections, and their geographical spread. In this study we built polygenic scores for heritable traits that influence the genetic adaptation in the production of cytokines and immune-mediated disorders, including infectious, inflammatory, and autoimmune diseases, and applied them to the genomes of several ancient European populations. We observed that the advent of the Neolithic was a turning point for immune-mediated traits in Europeans, favoring those alleles linked with the development of tolerance against intracellular pathogens and promoting inflammatory responses against extracellular microbes. These evolutionary patterns are also associated with an increased presence of traits related to inflammatory and auto-immune diseases.
• dc.description.sponsorship MGN was supported by an ERC Advanced Grant (833247) and a Spinoza Grant of the Netherlands Organization for Scientific Research. YL was supported by an ERC Starting Grant (948207) and the Radboud University Medical Centre Hypatia Grant (2018) for Scientific Research. JD-A is supported by The Netherlands Organization for Scientific Research (VENI grant 09150161910024). JB was supported by PID2019-110933GB-I00 (AEI/FEDER, UE) MINECO, Spain.
• dc.format.mimetype application/pdf
• dc.identifier.citation Domínguez-Andrés J, Kuijpers Y, Bakker OB, Jaeger M, Xu CJ, Van der Meer JW, Jakobsson M, Bertranpetit J, Joosten LA, Li Y, Netea MG. Evolution of cytokine production capacity in ancient and modern European populations. Elife. 2021;10:e64971. DOI: 10.7554/eLife.64971
• dc.identifier.doi http://dx.doi.org/10.7554/eLife.64971
• dc.identifier.issn 2050-084X
• dc.identifier.uri http://hdl.handle.net/10230/48941
• dc.language.iso eng
• dc.publisher eLife
• dc.relation.ispartof Elife. 2021;10:e64971
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/833247
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/948207
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-110933GB-I00
• dc.rights © 2021, Domínguez-Andrés et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Adaptation
• dc.subject.keyword Disease
• dc.subject.keyword Evolution
• dc.subject.keyword Genetics
• dc.subject.keyword Genomics
• dc.subject.keyword Human
• dc.subject.keyword Immune system
• dc.subject.keyword Immunology
• dc.subject.keyword Inflammation
• dc.subject.keyword Neolithic
• dc.title Evolution of cytokine production capacity in ancient and modern European populations
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion