Chimpanzee genomic diversity reveals ancient admixture with bonobos

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• dc.contributor.author de Manuel, Marc
• dc.contributor.author Kuhlwilm, Martin
• dc.contributor.author Sousa, Victor C.
• dc.contributor.author Prado Martínez, Javier, 1987-
• dc.contributor.author Hernández Rodríguez, Jéssica, 1983-
• dc.contributor.author Dupanloup, Isabelle
• dc.contributor.author Lao Grueso, Oscar, 1976-
• dc.contributor.author Heredia Genestar, José María, 1985-
• dc.contributor.author Kuderna, Lukas, 1989-
• dc.contributor.author Casals López, Ferran
• dc.contributor.author Angedakin, Samuel
• dc.contributor.author Arandjelovic, Mimi
• dc.contributor.author Boesch, Christophe
• dc.contributor.author Kühl, Hjalmar S.
• dc.contributor.author Vigilant, Linda
• dc.contributor.author Navarro i Cuartiellas, Arcadi, 1969-
• dc.contributor.author Excoffier, Laurent
• dc.contributor.author Marquès i Bonet, Tomàs, 1975-
• dc.date.accessioned 2018-12-05T08:33:04Z
• dc.date.available 2018-12-05T08:33:04Z
• dc.date.issued 2016
• dc.description.abstract Our closest living relatives, chimpanzees and bonobos, have a complex demographic history. We analyzed the high-coverage whole genomes of 75 wild-born chimpanzees and bonobos from 10 countries in Africa. We found that chimpanzee population substructure makes genetic information a good predictor of geographic origin at country and regional scales. Multiple lines of evidence suggest that gene flow occurred from bonobos into the ancestors of central and eastern chimpanzees between 200,000 and 550,000 years ago, probably with subsequent spread into Nigeria-Cameroon chimpanzees. Together with another, possibly more recent contact (after 200,000 years ago), bonobos contributed less than 1% to the central chimpanzee genomes. Admixture thus appears to have been widespread during hominid evolution.
• dc.description.sponsorship All sequence data have been submitted to the European Nucleotide Archive and are available under accession code PRJEB15086. M.d.M. is supported by a Formació de personal Investigador fellowship from Generalitat de Catalunya (FI_B01111). M.K. is supported by a Deutsche Forschungsgemeinschaft fellowship (KU 3467/1-1). V.C.S., I.D., and L.E. are supported by Swiss National Science Foundation grants 31003A-143393 and 310030B-16660. O.L. is supported by a Ramón y Cajal grant from Ministerio de Economía y Competitividad (MINECO) (RYC-2013-14797) and MINECO grant BFU2015-68759-P [Fondo Europeo de Desarrollo Region (FEDER)]. P.H. is supported by Estonian Research Council grant PUT1036. J.P.-M., C.T.-S., and Y.X. were supported by The Wellcome Trust (098051). J.M.H.-G. is supported by the María de Maeztu Programme (MDM-2014-0370). A.S. is supported by an Isaac Newton Trust/Wellcome Trust Institutional Strategic Support Fund Joint Research Grant. J.N. had support from a U.S. NIH U01CA198933 grant, and B.M.P. is supported by a Swiss National Science Foundation postdoctoral fellowship. A.N. is supported by MINECO grant BFU2015-68649-P. T.M.-B. thanks ICREA; the European Molecular Biology Organization Young Investigator Programme 2013; MINECO grants BFU2014-55090-P (FEDER), BFU2015-7116-ERC, and BFU2015-6215-ERCU01; U.S. NIH grant MH106874
• dc.format.mimetype application/pdf
• dc.identifier.citation de Manuel M, Kuhlwilm M, Frandsen P, Sousa VC, Desai T, Prado-Martinez J et al. Chimpanzee genomic diversity reveals ancient admixture with bonobos. Science. 2016 Oct 28;354(6311):477-48. DOI: 10.1126/science.aag2602
• dc.identifier.doi http://dx.doi.org/10.1126/science.aag2602
• dc.identifier.issn 0036-8075
• dc.identifier.uri http://hdl.handle.net/10230/35987
• dc.language.iso eng
• dc.publisher American Association for the Advancement of Science (AAAS)
• dc.relation.ispartof Science. 2016 Oct 28;354(6311):477-48
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2015-68759-P
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2015-68649-P
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2014-55090-P
• dc.rights This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on Volume 354, number 6311, 2016. DOI: 10.1126/science.aag2602
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.other Evolució molecular
• dc.subject.other Genètica
• dc.subject.other Bonobo -- Genètica
• dc.subject.other Ximpanzés -- Genètica
• dc.title Chimpanzee genomic diversity reveals ancient admixture with bonobos
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion