Association of time of breakfast and nighttime fasting duration with breast cancer risk in the multicase-control study in Spain

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• dc.contributor.author Palomar Cros, Anna
• dc.contributor.author Harding, Barbara N.
• dc.contributor.author Espinosa Díaz, Ana
• dc.contributor.author Straif, Kurt
• dc.contributor.author Castaño Vinyals, Gemma
• dc.contributor.author Romaguera Bosch, Dora
• dc.contributor.author Kogevinas, Manolis
• dc.date.accessioned 2022-12-01T06:55:54Z
• dc.date.available 2022-12-01T06:55:54Z
• dc.date.issued 2022
• dc.description.abstract Circadian nutritional behaviors, defined by the daily eating/fasting cycle, have been linked with breast cancer. This study aimed to further disentangle the association of nighttime fasting duration and time of breakfast with breast cancer risk. We analyzed data from 1,181 breast cancer cases and 1,326 population controls from the Spanish multicase-control study (MCC-Spain), 2008-2013. We collected circadian nutritional behaviors at mid-age via a telephonic interview. We applied logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CIs) for the association of nighttime fasting duration and time of breakfast with breast cancer risk in all women and stratified by menopausal status. Models were adjusted for age, center, education, family history of breast cancer, age at menarche, number of children, breastfeeding, age at first child, body mass index (BMI), contraceptive use, and hormonal replacement therapy (HRT). A later time of breakfast was associated with a non-significant increased risk of breast cancer (OR = 1.05, 95% CI: 0.95-1.16, per hour increase). This association was stronger among premenopausal women, among whom each hour later, the time of breakfast was associated with an 18% increase in breast cancer risk (OR = 1.18, 95% CI: 1.01-1.40). The association was not observed in postmenopausal women. We did not observe an association between nighttime fasting duration and breast cancer risk after adjusting for the time of breakfast. In this study, late breakfast was associated with increased breast cancer risk, especially among premenopausal women, compared with early breakfast. Aside from nutritional quality, circadian nutritional behaviors should be further studied in relation to cancer.
• dc.description.sponsorship This study was partially funded by the “Accion Transversal del Cancer,” approved on the Spanish Ministry Council on the 11 October 2007, Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PS09/00773, PS09/01286, PS09/01903, PS09/02078, PS09/01662, PI11/01889, PI11/02213, PI12/00488, PI12/01270, PI12/00715, PI14/01219, PI14/0613, and PI17/01388), Fundación Marqués de Valdecilla (API 10/09), the ICGC International Cancer Genome Consortium CLL [The ICGC CLL-Genome Project was funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) and Red Temática de Investigación del Cáncer (RTICC) del ISCIII (RD12/0036/0036)], the Junta de Castilla y León (LE22A10-2), the Consejería de Salud of the Junta de Andalucía (PI-0571-2009, PI-0306-2011, and salud201200057018tra), the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), the Recercaixa (2010ACUP 00310), the Regional Government of the Basque Country, the Consejería de Sanidad de la Región de Murcia, by the European Commission grants FOOD-CT-2006-036224-HIWATE, the Spanish Association Against Cancer (AECC) Scientific Foundation, by the Catalan Government—Agency for Management of University and Research Grants (AGAUR) grants 2017SGR723 and 2014SGR850, the Fundación Caja de Ahorros de Asturias, and the University of Oviedo. ISGlobal acknowledges support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S) and support from the Generalitat de Catalunya through the CERCA Program. AP-C was supported by the MINECO (Ministry of Economy in Spain) Grant no. PRE2019-089038, fellowship.
• dc.format.mimetype application/pdf
• dc.identifier.citation Palomar-Cros A, Harding BN, Espinosa A, Papantoniou K, Pérez-Gómez B, Straif K et al. Association of time of breakfast and nighttime fasting duration with breast cancer risk in the multicase-control study in Spain. Front Nutr. 2022 Aug 11;9:941477. DOI: 10.3389/fnut.2022.941477
• dc.identifier.doi http://dx.doi.org/10.3389/fnut.2022.941477
• dc.identifier.issn 2296-861X
• dc.identifier.uri http://hdl.handle.net/10230/55057
• dc.language.iso eng
• dc.publisher Frontiers
• dc.relation.ispartof Front Nutr. 2022 Aug 11;9:941477
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PRE2019-089038
• dc.rights © 2022 Palomar-Cros, Harding, Espinosa, Papantoniou, Pérez-Gómez, Straif, Ardanaz, Fernández Villa, Amiano, Gómez-Acebo, Moreno, Alguacil, Fernández-Tardón, Molina-Barceló, Marcos-Gragera, Aragonés, Castaño-Vinyals, Guevara, Marcos Delgado, Pollán, Romaguera and Kogevinas. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Breakfast
• dc.subject.keyword Breast cancer risk
• dc.subject.keyword Chrononutrition
• dc.subject.keyword Circadian nutritional behaviors
• dc.subject.keyword Circadian rhythms
• dc.subject.keyword Meal timing
• dc.subject.keyword Nighttime fasting duration
• dc.title Association of time of breakfast and nighttime fasting duration with breast cancer risk in the multicase-control study in Spain
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion