Exploring the relationship between the gut microbiome and mental health outcomes in a posttraumatic stress disorder cohort relative to trauma-exposed controls

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• dc.contributor.author Malan-Muller, Stefanie
• dc.contributor.author Vallès Colomer, Mireia
• dc.contributor.author Foxx, Christine L.
• dc.contributor.author Vieira Silva, Sara
• dc.contributor.author van den Heuvel, Leigh L.
• dc.contributor.author Raes, Jeroen
• dc.contributor.author Seedat, Soraya
• dc.contributor.author Lowry, Christopher A.
• dc.contributor.author Hemmings, Sian M. J.
• dc.date.accessioned 2024-07-11T14:26:42Z
• dc.date.available 2024-07-11T14:26:42Z
• dc.date.issued 2022
• dc.description.abstract Posttraumatic stress disorder (PTSD) imposes a significant burden on patients and communities. Although the microbiome-gut-brain axis has been proposed as a mediator or moderator of PTSD risk and persistence of symptoms, clinical data directly delineating the gut microbiome's relationship to PTSD are sparse. This study investigated associations between the gut microbiome and mental health outcomes in participants with PTSD (n = 79) and trauma-exposed controls (TECs) (n = 58). Diagnoses of PTSD, major depressive disorder (MDD), and childhood trauma were made using the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5), MINI International Neuropsychiatric Interview (MINI), and Childhood Trauma Questionnaire (CTQ), respectively. Microbial communities from stool samples were profiled using 16S ribosomal RNA gene V4 amplicon sequencing and tested for associations with PTSD-related variables of interest. Random forest models identified a consortium of four genera, i.e., a combination of Mitsuokella, Odoribacter, Catenibacterium, and Olsenella, previously associated with periodontal disease, that could distinguish PTSD status with 66.4% accuracy. The relative abundance of this consortium was higher in the PTSD group and correlated positively with CAPS-5 and CTQ scores. MDD diagnosis was also associated with increased relative abundance of the Bacteroidetes phylum. Current use of psychotropics significantly impacted community composition and the relative abundances of several taxa. Early life trauma may prime the microbiome for changes in composition that facilitate a pro-inflammatory cascade and increase the risk of development of PTSD. Future studies should rigorously stratify participants into healthy controls, TECs, and PTSD (stratified by psychotropic drug use) to explore the role of the oral-gut-microbiome-brain axis in trauma-related disorders.
• dc.format.mimetype application/pdf
• dc.identifier.citation Malan-Muller S, Valles-Colomer M, Foxx CL, Vieira-Silva S, van den Heuvel LL, Raes J, et al. Exploring the relationship between the gut microbiome and mental health outcomes in a posttraumatic stress disorder cohort relative to trauma-exposed controls. Eur Neuropsychopharmacol. 2022 Mar;56:24-38. DOI: 10.1016/j.euroneuro.2021.11.009
• dc.identifier.doi http://dx.doi.org/10.1016/j.euroneuro.2021.11.009
• dc.identifier.issn 0924-977X
• dc.identifier.uri http://hdl.handle.net/10230/60736
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Eur Neuropsychopharmacol. 2022 Mar;56:24-38
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.euroneuro.2021.11.009
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Depression
• dc.subject.keyword Gut microbiome
• dc.subject.keyword Microbiome-gut-brain axis
• dc.subject.keyword Oral microbiome
• dc.subject.keyword Posttraumatic stress disorder
• dc.subject.keyword Psychotropics
• dc.title Exploring the relationship between the gut microbiome and mental health outcomes in a posttraumatic stress disorder cohort relative to trauma-exposed controls
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion