Disruption of cellular immune response among male rotating night shift workers in Spain- The HORMONIT study

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• dc.contributor.author Harding, Barbara N.
• dc.contributor.author Aguilar, Ruth
• dc.contributor.author Espinosa Díaz, Ana
• dc.contributor.author Castaño Vinyals, Gemma
• dc.contributor.author Papantoniou, Kyriaki, 1983-
• dc.contributor.author Navarrete, José María
• dc.contributor.author Such Faro, Patricia
• dc.contributor.author Torrejón, Antonio
• dc.contributor.author Dobaño, Carlota
• dc.contributor.author Moncunill, Gemma
• dc.contributor.author Kogevinas, Manolis
• dc.date.accessioned 2022-12-01T06:55:50Z
• dc.date.available 2022-12-01T06:55:50Z
• dc.date.issued 2022
• dc.description.abstract Introduction: Preliminary studies suggest that night shift work is associated with a desynchronization of rhythmic immune markers, possibly explaining the increased risk of infection, cardiometabolic disorders, and cancer in shift workers. Methods: This study included 51 male rotating shift workers from a car industry in Barcelona, Spain, sampled twice toward the end of a 3-week night shift (22:00-06:00 h) and a 3-week day shift (06:00-14:00 h) rotation. We collected four blood samples per worker, at the start and end of each shift. We measured 27 cytokines, chemokines and growth factors in plasma samples by luminex using the Cytokine Human Magnetic 30-Plex Panel LHC6003M and applied linear mixed models to examine within-person associations between shift work and analytes' concentrations, comparing samples taken at 06:00 h on a day and night shift. We also conducted a factor analysis using analyte concentrations from all 4 time points for each individual to identify common factors and determine if these factors were altered by shift work. Results: We observed lower levels of 15 analytes in the night shift compared to the day shift including cytokines (pro-inflammatory TNF-α, IL-2R; anti-inflammatory IL1-RA; Th1 IL-2, Th2 IL-4 and Th17 Il-17), chemokines (IP-10, MIP-1α, MIP-1β, RANTES) and growth factors (EGF, G-CSF, HGF, VEGF, FGF). In a factor analysis, three factors were identified. The main factor (Factor 1), explaining 57% of the variance and including IL-1β, IL-12, IL-15, MIP-1α, MIP-1β, EGF and FGF; and another factor (Factor 3) explaining 10% of the variance and including the Th1 cytokine IL-12, were inversely associated with the night shift (coefficient: -0.17, 95%CI -0.32 to -0.01 and coefficient: -0.22, 95%CI -0.38, -0.06, for Factors 1 and 3, respectively). Our results indicate that night shift disrupts the levels of several immune markers, which could contribute to the increased risk of infections and cancer reported in night shift workers. Conclusion: Night shift is associated with disruption of multiple immune response pathways.
• dc.format.mimetype application/pdf
• dc.identifier.citation Harding BN, Aguilar R, Espinosa A, Castaño-Vinyals G, Papantoniou K, Navarrete JM, Such Faro P, Torrejón A, Dobaño C, Moncunill G, Kogevinas M. Disruption of cellular immune response among male rotating night shift workers in Spain- The HORMONIT study. Front Immunol. 2022 Sep 2;13:776917. DOI: 10.3389/fimmu.2022.776917
• dc.identifier.doi http://dx.doi.org/10.3389/fimmu.2022.776917
• dc.identifier.issn 1664-3224
• dc.identifier.uri http://hdl.handle.net/10230/55056
• dc.language.iso eng
• dc.publisher Frontiers
• dc.relation.ispartof Front Immunol. 2022 Sep 2;13:776917
• dc.rights © 2022 Harding, Aguilar, Espinosa, Castaño-Vinyals, Papantoniou, Navarrete, Such Faro, Torrejón, Dobaño, Moncunill and Kogevinas. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Chemokines
• dc.subject.keyword Cytokines
• dc.subject.keyword Growth factors
• dc.subject.keyword Immune response
• dc.subject.keyword Night shift
• dc.subject.keyword Rotating night shift workers
• dc.title Disruption of cellular immune response among male rotating night shift workers in Spain- The HORMONIT study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion