Depression and apathy after transient ischemic attack or minor stroke: prevalence, evolution and predictors

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• dc.contributor.author Carnes-Vendrell, Anna
• dc.contributor.author Deus, Joan
• dc.contributor.author Molina-Seguín, Jessica
• dc.contributor.author Pifarré, Josep
• dc.contributor.author Purroy, Francisco
• dc.date.accessioned 2021-03-05T07:44:25Z
• dc.date.available 2021-03-05T07:44:25Z
• dc.date.issued 2019
• dc.description.abstract Few previous studies have focused on affective impairment after transient ischemic attack (TIA) and/or minor stroke. The aim was to establish the prevalence, evolution and predictors of post-stroke depression (PSD) and post-stroke apathy (PSA) over a 12-month follow-up period. We prospectively included TIA and minor stroke patients (NIHSS ≤4) who had undergone magnetic resonance imaging <7 days. PSD was diagnosed according to DSM-5 criteria and PSA was defined based on an Apathy Evaluation Scale (AES-C) score of ≥37. Clinical and neuroimaging variables (presence and patterns of lesion, cerebral bleeds and white matter disease) were analysed in order to find potential predictors for PSD and PSA. Follow-up was performed at 10 days and after 2, 6, 9 and 12 months. 82 patients were included (mean 66.4 [standard deviation11.0] years) of whom 70 completed the follow-up. At 10 days, 36 (43.9%) and 28 (34.1%) patients respectively were diagnosed with PSD and PSA. At 12 months, 25 of 70 (35.7%) patients still had PSA, but only 6 of 70 (8.6%) had PSD. Beck Depression Inventory-II score, mini mental state examination (MMSE) and a previous history of depression or anxiety were predictors for PSD. While MMSE score, The Montgomery Asberg Depression Rating Scale and having previously suffered a stroke were also risk factors for PSA. Acute basal ganglia lesion and periventricular leukoaraiosis were associated with PSA while deep leukorariosis with PSD. Despite the presence of few or only transient symptoms, PSD and PSA frequent appear early after TIA and minor stroke. Unlike PSD, apathy tends to persist during follow-up.
• dc.format.mimetype application/pdf
• dc.identifier.citation Carnes-Vendrell A, Deus J, Molina-Seguin J, Pifarré J, Purroy F. Depression and apathy after transient ischemic attack or minor stroke: prevalence, evolution and predictors. Sci Rep. 2019 Nov 7; 9(1): 16248. DOI: 10.1038/s41598-019-52721-5
• dc.identifier.doi http://dx.doi.org/10.1038/s41598-019-52721-5
• dc.identifier.issn 2045-2322
• dc.identifier.uri http://hdl.handle.net/10230/46671
• dc.language.iso eng
• dc.publisher Nature Research
• dc.rights Copyright © The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.other Depressió psíquica
• dc.subject.other Apatia
• dc.subject.other Aturada cardíaca
• dc.subject.other Infart de miocardi
• dc.title Depression and apathy after transient ischemic attack or minor stroke: prevalence, evolution and predictors
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion