Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study

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• dc.contributor.author Navarrete-Muñoz, Eva-María
• dc.contributor.author Fitó Colomer, Montserrat
• dc.contributor.author Castañer, Olga
• dc.contributor.author Zomeño Fajardo, Maria Dolores
• dc.contributor.author Goday Arno, Alberto
• dc.contributor.author García de la Hera, Manuela
• dc.date.accessioned 2021-09-15T06:39:41Z
• dc.date.available 2021-09-15T06:39:41Z
• dc.date.issued 2021
• dc.description.abstract Purpose: We examined the association between dietary folate intake and a score of MetS (metabolic syndrome) and its components among older adults at higher cardiometabolic risk participating in the PREDIMED-Plus trial. Methods: A cross-sectional analysis with 6633 with overweight/obesity participants with MetS was conducted. Folate intake (per 100 mcg/day and in quintiles) was estimated using a validated food frequency questionnaire. We calculated a MetS score using the standardized values as shown in the formula: [(body mass index + waist-to-height ratio)/2] + [(systolic blood pressure + diastolic blood pressure)/2] + plasma fasting glucose-HDL cholesterol + plasma triglycerides. The MetS score as continuous variable and its seven components were the outcome variables. Multiple robust linear regression using MM-type estimator was performed to evaluate the association adjusting for potential confounders. Results: We observed that an increase in energy-adjusted folate intake was associated with a reduction of MetS score (β for 100 mcg/day = - 0.12; 95% CI: - 0.19 to - 0.05), and plasma fasting glucose (β = - 0.03; 95% CI: - 0.05 to - 0.02) independently of the adherence to Mediterranean diet and other potential confounders. We also found a positive association with HDL-cholesterol (β = 0.07; 95% CI: 0.04-0.10). These associations were also observed when quintiles of energy-adjusted folate intake were used instead. Conclusion: This study suggests that a higher folate intake may be associated with a lower MetS score in older adults, a lower plasma fasting glucose, and a greater HDL cholesterol in high-risk cardio-metabolic subjects.
• dc.format.mimetype application/pdf
• dc.identifier.citation Navarrete-Muñoz EM, Vioque J, Toledo E, Oncina-Canovas A, Martínez-González MÁ, Salas-Salvadó J et al. Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study. Eur J Nutr. 2021;60(2):1125-36. DOI: 10.1007/s00394-020-02364-4
• dc.identifier.doi http://dx.doi.org/10.1007/s00394-020-02364-4
• dc.identifier.issn 1436-6207
• dc.identifier.uri http://hdl.handle.net/10230/48455
• dc.language.iso eng
• dc.publisher Springer
• dc.relation.ispartof Eur J Nutr. 2021;60(2):1125-36
• dc.rights © Springer The final publication is available at Springer via http://dx.doi.org/10.1007/s00394-020-02364-4.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Cardiometabolic risk
• dc.subject.keyword Cholesterol
• dc.subject.keyword Diabetes
• dc.subject.keyword Folate
• dc.subject.keyword Metabolic syndrome score
• dc.title Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion