Incidence, functional outcomes and cure rate of hematogenous infection in a 2,498 Total Knee Arthroplasties cohort

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  • dc.contributor.author Pérez-Prieto, Daniel
  • dc.contributor.author Pardo, Albert
  • dc.contributor.author Fontanellas Fes, Albert
  • dc.contributor.author Gómez Junyent, Joan
  • dc.contributor.author Hinarejos Gómez, Pedro Angel
  • dc.contributor.author Monllau García, Juan Carlos
  • dc.date.accessioned 2024-05-21T06:24:29Z
  • dc.date.available 2024-05-21T06:24:29Z
  • dc.date.issued 2023
  • dc.description.abstract Purpose: The primary aim of the present study is to report the late acute hematogenous (LAH) prosthetic joint infection (PJI) cure rate following Total knee arthroplasty (TKA) treated by means of debridement, antibiotics, and implant retention (DAIR) in a long-term follow-up. The secondary purpose is to report the functional outcomes at that follow-up and to compare them with a non-infected group. Material and methods: This study cohort consists of 2,498 TKA performed from September 2005 to April 2010 that had a minimum follow-up of 10 years. The diagnosis of PJI and classification into LAH was done in accordance with the Zimmerli criteria. The primary outcome was the failure rate, defined as death before the end of antibiotic treatment, a further surgical intervention for treatment of infection, life-long antibiotic suppressive treatment or chronic infection. The Knee Society Score (KSS) was used to evaluate clinical outcomes. Results: Ten patients were diagnosed with acute hematogenous PJI during the study period (0.4%). All of them were managed with DAIR, which was performed by a knee surgeon and/or PJI surgeon. The failure rate was 0% at the 8.5-year (SD, 2.4) follow-up mark. The KSS score was 82.1 vs. 84.1 (p n.s.) at final follow-up. Conclusion: Although the literature suggests that TKA DAIR for LAH periprosthetic joint infection is associated with high rates of failure, the results presented here suggest a high cure rate with good functional outcomes. Level of evidence: Level II, prospective cohort study.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Pérez-Prieto D, Pardo A, Fontanellas A, Gómez-Junyent J, Hinarejos P, Monllau JC. Incidence, functional outcomes and cure rate of hematogenous infection in a 2,498 Total Knee Arthroplasties cohort. J Exp Orthop. 2023 Sep 25;10(1):96. DOI: 10.1186/s40634-023-00656-2
  • dc.identifier.doi http://dx.doi.org/10.1186/s40634-023-00656-2
  • dc.identifier.issn 2197-1153
  • dc.identifier.uri http://hdl.handle.net/10230/60199
  • dc.language.iso eng
  • dc.publisher Wiley
  • dc.relation.ispartof J Exp Orthop. 2023 Sep 25;10(1):96
  • dc.rights © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword DAIR
  • dc.subject.keyword Hematogenous PJI
  • dc.subject.keyword Late acute hematogenous infection
  • dc.subject.keyword PJI
  • dc.subject.keyword TKA infection
  • dc.title Incidence, functional outcomes and cure rate of hematogenous infection in a 2,498 Total Knee Arthroplasties cohort
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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