Comparative efficacy of linezolid and vancomycin for endotracheal tube MRSA biofilms from ICU patients

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Fernández-Barat, Laia
• dc.contributor.author Motos, Ana
• dc.contributor.author Panigada, Mauro
• dc.contributor.author Álvarez Lerma, Francisco
• dc.contributor.author Viña, Lucía
• dc.contributor.author Lopez-Aladid, Ruben
• dc.contributor.author Ceccato, Adrian
• dc.contributor.author Bassi, Gianluigi Li
• dc.contributor.author Nicolau, David P.
• dc.contributor.author Lopez, Yuli
• dc.contributor.author Muñoz, Laura
• dc.contributor.author Guerrero, Laura
• dc.contributor.author Soy, Dolors
• dc.contributor.author Israel, Trinidad
• dc.contributor.author Castro, Pedro
• dc.contributor.author Torres, Antoni
• dc.date.accessioned 2019-11-29T08:19:47Z
• dc.date.available 2019-11-29T08:19:47Z
• dc.date.issued 2019
• dc.description.abstract PURPOSE: To compare the efficacy of systemic treatment with linezolid (LNZ) versus vancomycin (VAN) on methicillin-resistant Staphylococcus aureus (MRSA) burden and eradication in endotracheal tube (ETT) biofilm and ETT cuff from orotracheally intubated patients with MRSA respiratory infection. METHODS: Prospective observational clinical study was carried out at four European tertiary hospitals. Plasma and endotracheal aspirate (ETA) levels of LNZ and VAN were determined 72 h after treatment initiation through high-performance liquid chromatography or bioassay. LNZ or VAN concentration in the ETT biofilm and MRSA burden and eradication was determined upon extubation. The minimum inhibitory concentration (MIC) for LNZ and VAN was assessed by E-test strips (Biomerieux®). Scanning electron microscopy images were obtained, and ETT biofilm thickness was compared between groups. RESULTS: Twenty-five patients, 15 treated with LNZ and 10 with VAN, were included in the study. LNZ presented a significantly higher concentration (μg/mL) than VAN in ETT biofilm (72.8 [1.3-127.1] vs 0.4 [0.4-1.3], p < 0.001), although both drugs achieved therapeutic plasma levels 72 h after treatment initiation. Systemic treatment with LNZ achieved lower ETT cuff MRSA burdens than systemic treatment with VAN. Indeed, LNZ increased the MRSA eradication rate in ETT cuff compared with VAN (LNZ 75%, VAN 20%, p = 0.031). CONCLUSIONS: In ICU patients with MRSA respiratory infection intubated for long periods, systemic treatment with LNZ obtains a greater beneficial effect than VAN in limiting MRSA burden in ETT cuff.
• dc.format.mimetype application/pdf
• dc.identifier.citation Fernández-Barat L, Motos A, Panigada M, Álvarez-Lerma F, Viña L, Lopez-Aladid R. et al. Comparative efficacy of linezolid and vancomycin for endotracheal tube MRSA biofilms from ICU patients. Crit Care. 2019 Jul 10;23(1):251. DOI 10.1186/s13054-019-2523-5
• dc.identifier.doi http://dx.doi.org/10.1111/cod.13192
• dc.identifier.issn 1364-8535
• dc.identifier.uri http://hdl.handle.net/10230/43032
• dc.language.iso eng
• dc.publisher BioMed Central
• dc.rights Copyright © The Author(s). 2019. Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Biofilm
• dc.subject.keyword Endotracheal tube
• dc.subject.keyword Linezolid
• dc.subject.keyword Methicillin-resistant Staphylococcus aureus
• dc.subject.keyword Respiratory infection
• dc.subject.keyword Vancomycin
• dc.title Comparative efficacy of linezolid and vancomycin for endotracheal tube MRSA biofilms from ICU patients
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion