Histone deacetylase gene expression following binge alcohol consumption in rats and humans

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• dc.contributor.author López Moreno, José A.ca
• dc.contributor.author Marcos, Miguelca
• dc.contributor.author Calleja Conde, Javierca
• dc.contributor.author Echeverry Alzate, Víctorca
• dc.contributor.author Bühler, Kora Mareenca
• dc.contributor.author Costa Alba, Pilarca
• dc.contributor.author Bernardo, Edgarca
• dc.contributor.author Laso, Francisco-Javierca
• dc.contributor.author Rodríguez de Fonseca, Fernandoca
• dc.contributor.author Nadal, Roserca
• dc.contributor.author Viveros, Maria Pazca
• dc.contributor.author Maldonado, Rafael, 1961-ca
• dc.contributor.author Giné, Elenaca
• dc.date.accessioned 2017-05-03T09:58:57Z
• dc.date.available 2017-05-03T09:58:57Z
• dc.date.issued 2015
• dc.description.abstract BACKGROUND: Alcohol binge drinking is one of the most common patterns of excessive alcohol use and recent data would suggest that histone deacetylases (HDACs) gene expression profiling could be useful as a biomarker for psychiatric disorders. METHODS: This study aimed to characterize the gene expression patterns of Hdac 1-11 in samples of rat peripheral blood, liver, heart, prefrontal cortex, and amygdala following repeated binge alcohol consumption and to determine the parallelism of Hdac gene expression between rats and humans in peripheral blood. To accomplish this goal, we examined Hdac gene expression following 1, 4, or 8 alcohol binges (3 g/kg, orally) in the rat, in patients who were admitted to the hospital emergency department for acute alcohol intoxication, and in rats trained in daily operant alcohol self-administration. RESULTS: We primarily found that acute alcohol binging reduced gene expression (Hdac1-10) in the peripheral blood of alcohol-naïve rats and that this effect was attenuated following repeated alcohol binges. There was also a reduction of Hdac gene expression in the liver (Hdac2,4,5), whereas there was increased expression in the heart (Hdac1,7,8) and amygdala (Hdac1,2,5). Additionally, increased blood alcohol concentrations were measured in rat blood at 1 to 4 hours following repeated alcohol binging, and the only group that developed hepatic steotosis (fatty liver) were those animals exposed to 8 alcohol binge events. Finally, both binge consumption of alcohol in humans and daily operant alcohol self-administration in rats increased Hdac gene expression in peripheral blood. CONCLUSIONS: Our results suggest that increases in HDAC gene expression within the peripheral blood are associated with chronic alcohol consumption, whereas HDAC gene expression is reduced following initial exposure to alcohol.
• dc.description.sponsorship This work was supported by The European Foundation for Alcohol Research (to JAL-M, FRdF, RM, RN, and MPV), the Fondo de Investigación Sanitaria (Red de Trastornos Adictivos, FEDER, RD12/0028/0015 to JAL-M, RD12/0028/001 to FRdF, RD12/0028/023 to RM, RD12/0028/0014 to RN, RD12/0028/1021 to MPV, RD12/0028/0008 to F-JL; and PI10/01692 to MM), and Ministerio de Ciencia e Innovación (SAF2011-26818 to JAL-M)
• dc.format.mimetype application/pdfca
• dc.identifier.citation López-Moreno JA, Marcos M, Calleja-Conde J, Echeverry-Alzate V, Bühler KM, Costa-Alba P et al. Histone deacetylase gene expression following binge alcohol consumption in rats and humans. Alcohol Clin Exp Res. 2015 Oct;39(10):1939-50. DOI: 10.1111/acer.12850
• dc.identifier.doi http://dx.doi.org/10.1111/acer.12850
• dc.identifier.issn 0145-6008
• dc.identifier.uri http://hdl.handle.net/10230/32088
• dc.language.iso eng
• dc.publisher Wileyca
• dc.relation.ispartof Alcoholism: Clinical and Experimental Research. 2015 Oct;39(10):1939-50
• dc.rights This is the pre-peer reviewed version of the following article: López-Moreno JA, Marcos M, Calleja-Conde J, Echeverry-Alzate V, Bühler KM, Costa-Alba P et al. Histone deacetylase gene expression following binge alcohol consumption in rats and humans. Alcohol Clin Exp Res. 2015 Oct; 39(10): 1939-50, which has been published in final form at http://dx.doi.org/10.1111/acer.12850. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.other Alcoholisme
• dc.subject.other Alcohol -- Consum
• dc.subject.other Expressió gènica
• dc.subject.other Enzims
• dc.title Histone deacetylase gene expression following binge alcohol consumption in rats and humansca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion