Cancer effects of low to moderate doses of ionizing radiation in young people with cancer-predisposing conditions: a systematic review

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  • dc.contributor.author Canet, Maelle
  • dc.contributor.author Harbron, Richard W.
  • dc.contributor.author Thierry-Chef, Isabelle
  • dc.contributor.author Cardis, Elisabeth
  • dc.date.accessioned 2022-11-22T07:14:34Z
  • dc.date.available 2022-11-22T07:14:34Z
  • dc.date.issued 2022
  • dc.description.abstract Moderate to high doses of ionizing radiation (IR) are known to increase the risk of cancer, particularly following childhood exposure. Concerns remain regarding risks from lower doses and the role of cancer-predisposing factors (CPF; genetic disorders, immunodeficiency, mutations/variants in DNA damage detection or repair genes) on radiation-induced cancer (RIC) risk. We conducted a systematic review of evidence that CPFs modify RIC risk in young people. Searches were performed in PubMed, Scopus, Web of Science, and EMBASE for epidemiologic studies of cancer risk in humans (<25 years) with a CPF, exposed to low-moderate IR. Risk of bias was considered. Fifteen articles focusing on leukemia, lymphoma, breast, brain, and thyroid cancers were included. We found inadequate evidence that CPFs modify the risk of radiation-induced leukemia, lymphoma, brain/central nervous system, and thyroid cancers and limited evidence that BRCA mutations modify radiation-induced breast cancer risk. Heterogeneity was observed across studies regarding exposure measures, and the numbers of subjects with CPFs other than BRCA mutations were very small. Further studies with more appropriate study designs are needed to elucidate the impact of CPFs on RIC. They should focus either on populations of carriers of specific gene mutations or on common susceptible variants using polygenic risk scores.
  • dc.description.sponsorship This work was performed within the MEDIRAD project, which has received funding from the Euratom research and training program 2014–2018 under grant agreement No 755523.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Canet M, Harbron R, Thierry-Chef I, Cardis E. Cancer effects of low to moderate doses of ionizing radiation in young people with cancer-predisposing conditions: a systematic review. Cancer Epidemiol Biomarkers Prev. 2022 Oct 4;31(10):1871-89. DOI: 10.1158/1055-9965.EPI-22-0393
  • dc.identifier.doi http://dx.doi.org/10.1158/1055-9965.EPI-22-0393
  • dc.identifier.issn 1055-9965
  • dc.identifier.uri http://hdl.handle.net/10230/54956
  • dc.language.iso eng
  • dc.publisher American Association for Cancer Research (AACR)
  • dc.relation.ispartof Cancer Epidemiol Biomarkers Prev. 2022 Oct 4;31(10):1871-89
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/755523
  • dc.rights © 2022 The Authors; Published by the American Association for Cancer Research This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License .
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0
  • dc.title Cancer effects of low to moderate doses of ionizing radiation in young people with cancer-predisposing conditions: a systematic review
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
Articles (Departament de Medicina i Ciències de la Vida)
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