Prognostic relevance of preoperative immune, inflammatory, and nutritional biomarkers in patients undergoing gastrectomy for resectable gastric adenocarcinoma: an observational multicentre study

Tur-Martínez, Jaume; Rodríguez-Santiago, Joaquín; Osorio, Javier; Miró, Mònica; Yarnoz, Concepción; Jofra, Mariona; Ferret, Georgina; Salvador-Roses, Helena; Fernández-Ananín,  Sonia; Clavell, Arantxa; Luna, Alexis; Aldeano, Aurora; Olona, Carles; Hermoso, Judith; Güell-Farré, Mercè; Dal Cero, Mariagiulia; Gimeno, Marta; Pallarès, Natàlia; Pera Roman, Manuel Ramón

Prognostic relevance of preoperative immune, inflammatory, and nutritional biomarkers in patients undergoing gastrectomy for resectable gastric adenocarcinoma: an observational multicentre study

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dc.contributor.author Tur-Martínez, Jaume
dc.contributor.author Rodríguez-Santiago, Joaquín
dc.contributor.author Osorio, Javier
dc.contributor.author Miró, Mònica
dc.contributor.author Yarnoz, Concepción
dc.contributor.author Jofra, Mariona
dc.contributor.author Ferret, Georgina
dc.contributor.author Salvador-Roses, Helena
dc.contributor.author Fernández-Ananín, Sonia
dc.contributor.author Clavell, Arantxa
dc.contributor.author Luna, Alexis
dc.contributor.author Aldeano, Aurora
dc.contributor.author Olona, Carles
dc.contributor.author Hermoso, Judith
dc.contributor.author Güell-Farré, Mercè
dc.contributor.author Dal Cero, Mariagiulia
dc.contributor.author Gimeno, Marta
dc.contributor.author Pallarès, Natàlia
dc.contributor.author Pera Roman, Manuel Ramón
dc.date.accessioned 2025-10-24T14:09:58Z
dc.date.available 2025-10-24T14:09:58Z
dc.date.issued 2024
dc.date.updated 2025-10-24T14:09:58Z
dc.description.abstract Background: The aim of this study was to evaluate different preoperative immune, inflammatory, and nutritional scores and their best cut-off values as predictors of poorer overall survival (OS) and disease-free survival (DFS) in patients who underwent curative gastric cancer resection. Methods: This was a retrospective observational multicentre study based on data of the Spanish EURECCA Esophagogastric Cancer Registry. Time-dependent Youden index and log-rank test were used to obtain the best cut-offs of 18 preoperative biomarkers for OS and DFS. An adjusted Cox model with variables selected by bootstrapping was used to identify the best preoperative biomarkers, which were also analysed for every TNM stage. Results: High neutrophil-to-lymphocyte ratio (NLR), high monocyte systemic inflammation index (moSII), and low prognostic nutritional index (PNI) were identified as independent predictors of poor outcome: NLR > 5.91 (HR:1.73; 95%CI [1.23-2.43]), moSII >2027.12 (HR:2.26; 95%CI [1.36-3.78]), and PNI >40.31 (HR:0.75; 95%CI [0.58-0.96]) for 5-year OS and NLR > 6.81 (HR:1.75; 95%CI [1.24-2.45]), moSII > 2027.12 (HR:2.46; 95%CI [1.49-4.04]), and PNI > 40.31 (HR:0.77; 95%CI [0.60,0.97]) for 5-year DFS. These outcomes were maintained in the whole cohort for NLR and moSII (p < 0.05) but not in stage II and for PNI in all tumoral stages. The associations of NLR-PNI and moSII-PNI were also a relevant prognostic factor for OS. Conclusions: High NLR, high moSII (for stages I and III), and low PNI (regardless of tumour stage) were the most promising preoperative biomarkers to predict poor OS and DFS in gastric cancer patients treated with curative intent.
dc.format.mimetype application/pdf
dc.identifier.citation Tur-Martínez J, Rodríguez-Santiago J, Osorio J, Miró M, Yarnoz C, Jofra M, Ferret G, Salvador-Roses H, Fernández-Ananín S, Clavell A, Luna A, Aldeano A, Olona C, Hermoso J, Güell-Farré M, Dal Cero M, Gimeno M, Pallarès N, Pera M. Prognostic relevance of preoperative immune, inflammatory, and nutritional biomarkers in patients undergoing gastrectomy for resectable gastric adenocarcinoma: an observational multicentre study. Cancers (Basel). 2024 Jun 11;16(12):2188. DOI: 10.3390/cancers16122188
dc.identifier.doi http://dx.doi.org/10.3390/cancers16122188
dc.identifier.issn 2072-6694
dc.identifier.uri http://hdl.handle.net/10230/71648
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Cancers. 2024;16(12):2188
dc.rights © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword Gastric cancer
dc.subject.keyword Preoperative biomarker
dc.subject.keyword Preoperative immune score
dc.subject.keyword Preoperative inflammation score
dc.subject.keyword Preoperative nutritional score
dc.title Prognostic relevance of preoperative immune, inflammatory, and nutritional biomarkers in patients undergoing gastrectomy for resectable gastric adenocarcinoma: an observational multicentre study
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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