Membrane protein structure, function, and dynamics: a perspective from experiments and theory

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• dc.contributor.author Cournia, Zoe
• dc.contributor.author Selent, Jana
• dc.contributor.author Bondar, Ana-Nicoleta
• dc.date.accessioned 2019-01-17T08:44:12Z
• dc.date.available 2019-01-17T08:44:12Z
• dc.date.issued 2015
• dc.description.abstract Membrane proteins mediate processes that are fundamental for the flourishing of biological cells. Membrane-embedded transporters move ions and larger solutes across membranes; receptors mediate communication between the cell and its environment and membrane-embedded enzymes catalyze chemical reactions. Understanding these mechanisms of action requires knowledge of how the proteins couple to their fluid, hydrated lipid membrane environment. We present here current studies in computational and experimental membrane protein biophysics, and show how they address outstanding challenges in understanding the complex environmental effects on the structure, function, and dynamics of membrane proteins.
• dc.description.sponsorship JTD, IA, and MR used the computational resources of the Modeling Facility of the Department of Chemistry, University of California Irvine funded by NSF Grant CHE-0840513 for this work. A-NB was supported in part by the Marie Curie International Reintegration Award IRG-26920.TWA was supported by ARC DP120103548, NSF MCB1052477, DE Shaw Anton (PSCA00061P; NRBSC, through NIH RC2GM093307), VLSCI (VR0200), and NCI (dd7). BA and SV acknowledge the support by ERC advanced Grant No. 268888. ZC and PG would like to acknowledge Reference Framework (NSRF) 2011–2013, National Action ‘‘Cooperation,’’ under grant entitled ‘‘Magnetic Nanoparticles for targeted MRI therapy (NANOTHER),’’ with code ‘‘11RYM-1-1799.’’ The program is cofunded by the European Regional Development Fund and national resources. Part of the calculations presented herein were performed using resources of the LinkSCEEM-2 project, funded by the EC under FP7 through Capacities Research Infrastructure, INFRA-2010-1.2.3 Virtual Research Communities, Combination of Collaborative Project and Coordination and Support Actions (CPCSA) under Grant agreement no. RI-261600. GB was supported in part by NSF grant MCB1330728 from the National Science Foundation and Grant PO1GM55876-14A1 from the National Institutes of Health. LD received funding from EU FP7 (PIOF-GA-2012-329534). LD, and MLK used the computational resources of Temple University, supported by the National Science Foundation through major research instrumentation grant number CNS-09-58854. JS acknowledges support from the Instituto de Salud Carlos III FEDER (CP12/03139)
• dc.format.mimetype application/pdf
• dc.identifier.citation Cournia Z, Allen TW, Andricioaei I, Antonny B, Baum D, Brannigan G et al. Membrane protein structure, function, and dynamics: a perspective from experiments and theory. J Membr Biol. 2015 Aug;248(4):611-40. DOI: 10.1007/s00232-015-9802-0
• dc.identifier.doi http://dx.doi.org/10.1007/s00232-015-9802-0
• dc.identifier.issn 0022-2631
• dc.identifier.uri http://hdl.handle.net/10230/36306
• dc.language.iso eng
• dc.publisher Springer
• dc.relation.ispartof Journal of Membrane Biology. 2015 Aug;248(4):611-40
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/329534
• dc.rights © Springer The final publication is available at Springer via http://dx.doi.org/10.1007/s00232-015-9802-0
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.other Proteïnes portadores
• dc.subject.other Models biològics
• dc.subject.other Química--Models
• dc.title Membrane protein structure, function, and dynamics: a perspective from experiments and theory
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion