Prenatal exposure to phthalates and phenols and preclinical vascular health during early adolescence

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• dc.contributor.author Montazeri, Parisa, 1988-
• dc.contributor.author Fossati, Serena
• dc.contributor.author Warembourg, Charline
• dc.contributor.author Casas Sanahuja, Maribel
• dc.contributor.author Clemente Batalha Pardal, Diana, 1990-
• dc.contributor.author Garcia-Esteban, Raquel
• dc.contributor.author Nawrot, Tim S.
• dc.contributor.author Vrijheid, Martine
• dc.date.accessioned 2022-02-18T06:47:34Z
• dc.date.available 2022-02-18T06:47:34Z
• dc.date.issued 2022
• dc.description.abstract Background and aim: Exposure to endocrine-disrupting chemicals may increase cardiovascular risk from early life, but studies in children have shown inconsistent results, most focused on analysis of single chemicals, and none included measures of micro-vascularization as early preclinical markers. This study aimed to evaluate the association between prenatal exposure to phthalates and phenols and macro- and microvascular health during early adolescence. Methods: Using data from a Spanish birth cohort (n = 416), prenatal exposure to eight phthalate metabolites and seven phenols (bisphenol A, four parabens, benzophenone-3, triclosan) were assessed using first and/or third trimester spot-urine concentrations. Macrovascular health (systolic and diastolic blood pressure (SBP and DBP, mmHg), pulse wave velocity (PWV, m/s)) and microvascular health (central retinal artery/vein equivalent (CRAE/CRVE, μm)), were measured at 11 years old. Linear regression models assessed associations for individual chemicals and Bayesian weighted quantile sum regression (BWQS) evaluated the overall association of the phthalate and phenol mixture with cardiovascular health. Results: In single exposure models, bisphenol-A was associated with decreased PWV (β per doubling of exposure = -0.06; 95% CI: -0.10, -0.01). Mono-iso-butyl phthalate was associated with an increase in CRAE (β = 1.89; 95% CI: 0.34, 3.44). Methyl- and butyl-parabens were associated with a decrease in CRVE (β = -0.71; 95% CI: -1.41, -0.01) and (β = -0.96; 95% CI: -1.57, -0.35), respectively. No statistically significant associations were observed between any of the exposures and SBP or DBP. BWQS models showed no evidence of associations between the phthalate and phenol mixture and any of the outcomes. Conclusions: Our results provide little evidence to suggest that prenatal exposure to phthalates and phenols is associated with macro- or microvascular health during early adolescence, except a few associations with certain compounds. Errors in exposure measurement and reduced variability in cardiovascular measures at this early age limit our ability to draw strong conclusions.
• dc.description.sponsorship This study was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds; PI12/01890 incl. FEDER funds; CP13/00054 incl. FEDER funds; PI15/00118 incl. FEDER funds; CP16/00128 incl. FEDER funds; PI16/00118 incl. FEDER funds; PI16/00261 incl. FEDER funds; PI17/01340 incl. FEDER funds; PI18/00547 incl. FEDER funds), CIBERESP, Generalitat de Catalunya-CIRIT 1999SGR 00241, Generalitat de Catalunya-AGAUR (2009 SGR 501, 2014 SGR 822), Fundació La marató de TV3 (090430), Spanish Ministry of Economy and Competitiveness (SAF2012-32991 incl. FEDER funds), Agence Nationale de Securite Sanitaire de l’Alimentation de l’Environnement et du Travail (1262C0010; EST-2016 RF-21), EU Commission (261357, 308333, 603794 and 634453). CW held a Sara Borrell postdoctoral grant (CD18/00132) from the Instituto de Salud Carlos III. We acknowledge support from the Spanish Ministry of Science and Innovation and the State Research Agency through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program.
• dc.format.mimetype application/pdf
• dc.identifier.citation Montazeri P, Fossati S, Warembourg C, Casas M, Clemente DBP, Garcia-Esteban R, Nawrot TS, Vrijheid M. Prenatal exposure to phthalates and phenols and preclinical vascular health during early adolescence. Int J Hyg Environ Health. 2022;240:113909. DOI: 10.1016/j.ijheh.2021.113909
• dc.identifier.doi http://dx.doi.org/10.1016/j.ijheh.2021.113909
• dc.identifier.issn 1438-4639
• dc.identifier.uri http://hdl.handle.net/10230/52520
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Int J Hyg Environ Health. 2022;240:113909
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012-32991
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/603794
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/634453
• dc.rights © 2022 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Cardiovascular diseases
• dc.subject.keyword Chemical exposures
• dc.subject.keyword Endocrine disrupting chemicals
• dc.subject.keyword Mixtures analysis
• dc.subject.keyword Phenols
• dc.subject.keyword Phthalates
• dc.title Prenatal exposure to phthalates and phenols and preclinical vascular health during early adolescence
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion