Genetic or other causation should not change the clinical diagnosis of cerebral palsy
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- dc.contributor.author MacLennan, Alastair H.
- dc.contributor.author Pérez Jurado, Luis Alberto
- dc.contributor.author Gecz, Jozef
- dc.date.accessioned 2019-07-11T06:19:11Z
- dc.date.available 2019-07-11T06:19:11Z
- dc.date.issued 2019
- dc.description.abstract High throughput sequencing is discovering many likely causative genetic variants in individuals with cerebral palsy. Some investigators have suggested that this changes the clinical diagnosis of cerebral palsy and that these individuals should be removed from this diagnostic category. Cerebral palsy is a neurodevelopmental disorder diagnosed on clinical signs, not etiology. All nonprogressive permanent disorders of movement and posture attributed to disturbances that occurred in the developing fetal and infant brain can be described as "cerebral palsy." This definition of cerebral palsy should not be changed, whatever the cause. Reasons include stability, utility and accuracy of cerebral palsy registers, direct access to services, financial and social support specifically offered to families with cerebral palsy, and community understanding of the clinical diagnosis. Other neurodevelopmental disorders, for example, epilepsy, have not changed the diagnosis when genomic causes are found. The clinical diagnosis of cerebral palsy should remain, should prompt appropriate genetic studies and can subsequently be subclassified by etiology.
- dc.format.mimetype application/pdf
- dc.identifier.citation MacLennan AH, Lewis S, Moreno-De-Luca A, Fahey M, Leventer RJ, McIntyre S et al. Genetic or other causation should not change the clinical diagnosis of cerebral palsy. J Child Neurol. 2019; 34(8):472-476. DOI 10.1177/0883073819840449
- dc.identifier.doi http://dx.doi.org/10.1177/0883073819840449
- dc.identifier.issn 0883-0738
- dc.identifier.uri http://hdl.handle.net/10230/41984
- dc.language.iso eng
- dc.publisher SAGE Publications
- dc.relation.ispartof J Child Neurol. 2019; 34(8):472-476
- dc.rights © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://www.creativecommons.org/licenses/by-nc/4.0/
- dc.subject.keyword Causation
- dc.subject.keyword Cerebral palsy
- dc.subject.keyword Clinical definition
- dc.subject.keyword Genomics
- dc.title Genetic or other causation should not change the clinical diagnosis of cerebral palsy
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion