Accumulation of paneth cells in early colorectal adenomas is associated with beta-catenin signaling and poor patient prognosis

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• dc.contributor.author López Arribillaga, Erika, 1986-
• dc.contributor.author Yan, Bing
• dc.contributor.author Lobo-Jarne, Teresa
• dc.contributor.author Guillén, Yolanda
• dc.contributor.author Menéndez, Silvia
• dc.contributor.author Andreu García, Montserrat
• dc.contributor.author Bigas Salvans, Anna
• dc.contributor.author Iglesias Coma, Mar
• dc.contributor.author Espinosa Blay, Lluís
• dc.date.accessioned 2022-07-21T06:28:22Z
• dc.date.available 2022-07-21T06:28:22Z
• dc.date.issued 2021
• dc.description.abstract Background: previous studies in mice indicated that Paneth cells and c-Kit-positive goblet cells represent the stem cell niche of the small intestine and colon, respectively, partly by supporting Wnt and Notch activation. Whether these cell populations play a similar role in human intestinal cancer remains unexplored. Methods: we performed histopathological evaluation and immunohistochemical analysis of early colorectal adenomas and carcinoma adenoma from patients at the Hospital del Mar in Barcelona. We then determined the possible correlation between the different parameters analyzed and with patient outcomes. Results: paneth cells accumulate in a subset of human colorectal adenomas directly associated with Notch and Wnt/β-catenin activation. Adenoma areas containing Paneth cells display increased vessel density in the lamina propria and higher levels of the stem cell marker EphB2. In an in-house cohort of 200 colorectal adenoma samples, we also observed a significant correlation between the presence of Paneth cells and Wnt activation. Kaplan-Meier analysis indicated that early adenoma patients carrying Paneth cell-positive tumors display reduced disease-free survival compared with patients with Paneth cell-free lesions. Conclusions: our results indicate that Paneth cells contribute to the initial steps of cancer progression by providing the stem cell niche to adenoma cells, which could be therapeutically exploited.
• dc.format.mimetype application/pdf
• dc.identifier.citation López-Arribillaga E, Yan B, Lobo-Jarne T, Guillén Y, Menéndez S, Andreu M, et al. Accumulation of paneth cells in early colorectal adenomas is associated with beta-catenin signaling and poor patient prognosis. Cells. 2021 Oct 28; 10(11): 2928. DOI: 10.3390/cells10112928
• dc.identifier.doi http://dx.doi.org/10.3390/cells10112928
• dc.identifier.issn 2073-4409
• dc.identifier.uri http://hdl.handle.net/10230/53773
• dc.language.iso eng
• dc.publisher MDPI
• dc.rights Copyright: © 2021 by the authors.Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Notch
• dc.subject.keyword Paneth cells
• dc.subject.keyword Wnt
• dc.subject.keyword Adenomas
• dc.subject.keyword Colorectal cancer
• dc.subject.keyword Stem cell niche
• dc.title Accumulation of paneth cells in early colorectal adenomas is associated with beta-catenin signaling and poor patient prognosis
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion