ΔNp63α promotes adhesion of metastatic prostate cancer cells to the bone through regulation of CD82

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  • dc.contributor.author Di Giacomo, Valeria, 1983-
  • dc.contributor.author Tian, Tian V.
  • dc.contributor.author Mas Malavila, Alba
  • dc.contributor.author Pecoraro, Matteo, 1984-
  • dc.contributor.author Batlle Morera, Laura
  • dc.contributor.author Noya Ferreiro, Lourdes
  • dc.contributor.author Martín Caballero, Juan
  • dc.contributor.author Ruberte, Jesús
  • dc.contributor.author Keyes, William M., 1973-
  • dc.date.accessioned 2023-12-12T06:40:21Z
  • dc.date.available 2023-12-12T06:40:21Z
  • dc.date.issued 2017
  • dc.description.abstract ΔNp63α is a critical mediator of epithelial development and stem cell function in a variety of tissues including the skin and breast, while overexpression of ΔNp63α acts as an oncogene to drive tumor formation and cancer stem cell properties in squamous cell carcinoma. However, with regards to the prostate, while ΔNp63α is expressed in the basal stem cells of the mature gland, during adenocarcinoma development, its expression is lost and its absence is used to clinically diagnose the malignant state. Surprisingly, here we identify a sub-population of bone metastatic prostate cancer cells in the PC3 cell line that express ΔNp63α. Interestingly, we discovered that ΔNp63α favors adhesion and stem-like growth of these cells in the bone microenvironment. In addition, we show that these properties require expression of the target gene CD82. Together, this work uncovers a population of bone metastatic prostate cancer cells that express ΔNp63α, and provides important information about the mechanisms of bone metastatic colonization. Finally, we identify metastasis-promoting properties for the tetraspanin family member CD82.
  • dc.description.sponsorship We thank Roger Gomis and Marc Guiu for help with tumor imaging analysis, Jason Doles for help in the short hairpin design and the CRG Bioinformatics facility for assistance with microarray and sequencing data analysis. VDG was supported by a fellowship from ‘La Caixa’, and MP with an F.P.I. fellowship from the Spanish Ministry. This work was funded by Grants SAF2010-18829 (WMK) and SAF2013-49082-P (WMK) from the Ministerio de Economía y Competitividad and a Marie Curie International Reintegration Grant PIRG5-GA-2009-248262 (WMK).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Di Giacomo V, Tian TV, Mas A, Pecoraro M, Batlle-Morera L, Noya L, et al. ΔNp63α promotes adhesion of metastatic prostate cancer cells to the bone through regulation of CD82. Oncogene. 2017 Aug;36(31):4381-92. DOI: 10.1038/onc.2017.42
  • dc.identifier.doi http://dx.doi.org/10.1038/onc.2017.42
  • dc.identifier.issn 0950-9232
  • dc.identifier.uri http://hdl.handle.net/10230/58504
  • dc.language.iso eng
  • dc.publisher Springer
  • dc.relation.ispartof Oncogene. 2017 Aug;36(31):4381-92
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/248262
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2010-18829
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2013-49082-P
  • dc.rights This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
  • dc.subject.other Pròstata -- Càncer
  • dc.subject.other Metàstasi
  • dc.subject.other Cèl·lules mare
  • dc.title ΔNp63α promotes adhesion of metastatic prostate cancer cells to the bone through regulation of CD82
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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