Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity

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  • dc.contributor.author Miranda-Olivos, Romina
  • dc.contributor.author Baenas, Isabel
  • dc.contributor.author Steward, Trevor
  • dc.contributor.author Granero, Roser
  • dc.contributor.author Pastor, Antonio
  • dc.contributor.author Sánchez, Isabel
  • dc.contributor.author Juaneda-Seguí, Asier
  • dc.contributor.author Pino-Gutiérrez, Amparo del
  • dc.contributor.author Fernández-Formoso, José A.
  • dc.contributor.author Vilarrasa, Nuria
  • dc.contributor.author Guerrero-Pérez, Fernando
  • dc.contributor.author Virgili, Núria
  • dc.contributor.author López-Urdiales, Rafael
  • dc.contributor.author Jiménez Murcia, Susana
  • dc.contributor.author Torre Fornell, Rafael de la
  • dc.contributor.author Soriano Mas, Carles
  • dc.contributor.author Fernández Aranda, Fernando
  • dc.date.accessioned 2023-12-01T06:57:28Z
  • dc.date.available 2023-12-01T06:57:28Z
  • dc.date.issued 2023
  • dc.description.abstract Anorexia nervosa (AN) is a severe psychiatric disorder characterized by a harmful persistence of self-imposed starvation resulting in significant weight loss. Research suggests that alterations in the nucleus accumbens (NAcc) and circulating endocannabinoids (eCBs), such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG), may contribute to increased severity and maladaptive behaviors in AN, warranting an examination of the interplay between central reward circuitry and eCBs. For this purpose, we assessed NAcc functional connectivity and circulating AEA and 2-AG concentrations in 18 individuals with AN and 18 healthy controls (HC) to test associations between circulating eCBs, NAcc functional connectivity, and AN severity, as defined by body mass index (BMI). Decreased connectivity was observed between the NAcc and the right insula (NAcc-insula; pFWE < 0.001) and the left supplementary motor area (NAcc-SMA; pFWE < 0.001) in the AN group compared to HC. Reduced NAcc-insula functional connectivity mediated the association between AEA concentrations and BMI in the AN group. However, in HC, NAcc-SMA functional connectivity had a mediating role between AEA concentrations and BMI. Although no significant differences in eCBs concentrations were observed between the groups, our findings provide insights into how the interaction between eCBs and NAcc functional connectivity influences AN severity. Altered NAcc-insula and NAcc-SMA connectivity in AN may impair the integration of interoceptive, somatosensory, and motor planning information related to reward stimuli. Furthermore, the distinct associations between eCBs concentrations and NAcc functional connectivity in AN and HC could have clinical implications for weight maintenance, with eCBs being a potential target for AN treatment.
  • dc.description.sponsorship This manuscript and research were supported by grants from Instituto de Salud Carlos III (ISCIII) (FIS PI20/00132) and co-funded by FEDER funds/European Regional Development Fund (ERDF), a way to build Europe. CIBERObn and CIBERSAM are both initiatives of ISCIII. Additional support was received from the Delegación del Gobierno para el Plan Nacional sobre Drogas (2021I031) and Ministerio de Ciencia e Innovación (grant PID2021-124887OB-I00). Additional funding was received by AGAUR-Generalitat de Catalunya (2021-SGR-00824), European Union’s Horizon 2020 research and innovation program under Grant agreement no. 847879 (PRIME/H2020, Prevention and Remediation of Insulin Multimorbidity in Europe) and the European Union’s Horizon Europe research and innovation program under grant agreement No 101080219 (eprObes). This work was partially supported by Instituto de Salud Carlos III through the grant CM21/00172 (IB) (co-funded by European Social Fund. ESF investing in your future). RG is supported by the Catalan Institution for Research and Advanced Studies (ICREA-Academia, 2021-Programme). TS is supported by a National Health and Medical Research Council (NHMRC)/Medical Research Future Fund (MRFF) Investigator Grant (MRF1193736), a Brain & Behavior Research Foundation (BBRF) Young Investigator Grant, and a University of Melbourne McKenzie Fellowship. The funders had no role in the study design, data collection, analysis, decision to publish, or preparation of the manuscript.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Miranda-Olivos R, Baenas I, Steward T, Granero R, Pastor A, Sánchez I, et al. Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity. Mol Psychiatry. 2023 Nov;28(11):4793-800. DOI: 10.1038/s41380-023-02253-2
  • dc.identifier.doi http://dx.doi.org/10.1038/s41380-023-02253-2
  • dc.identifier.issn 1359-4184
  • dc.identifier.uri http://hdl.handle.net/10230/58422
  • dc.language.iso eng
  • dc.publisher Nature Research
  • dc.relation.ispartof Mol Psychiatry. 2023 Nov;28(11):4793-800
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/847879
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2021-124887OB-I0
  • dc.rights © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Neuroscience
  • dc.subject.keyword Psychiatric disorders
  • dc.title Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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