Contribution of CD4+ cells in the emotional alterations induced by endometriosis in mice
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Escudero Lara, Alejandra, 1992-
- dc.contributor.author Cabañero Ferri, David
- dc.contributor.author Maldonado, Rafael, 1961-
- dc.date.accessioned 2022-12-19T07:28:50Z
- dc.date.available 2022-12-19T07:28:50Z
- dc.date.issued 2022
- dc.description.abstract Endometriosis is a disease defined by the presence of endometrial tissue in extrauterine locations. This chronic condition is frequently associated with pain and emotional disorders and has been related with altered immune function. However, the specific involvement of immune cells in pain and behavioral symptoms of endometriosis has not been yet elucidated. Here, we implement a mouse model of non-surgical endometriosis in which immunocompetent mice develop abdomino-pelvic hypersensitivity, cognitive deficits, anxiety and depressive-like behaviors. This behavioral phenotype correlates with expression of inflammatory markers in the brain, including the immune cell marker CD4. Depletion of CD4 + cells decreases the anxiety-like behavior of mice subjected to the endometriosis model, whereas abdomino-pelvic hypersensitivity, depressive-like behavior and cognitive deficits remain unaltered. The present data reveal the involvement of the immune response characterized by CD4 + white blood cells in the anxiety-like behavior induced by endometriosis in mice. This model, which recapitulates the symptoms of human endometriosis, may be a useful tool to study the immune mechanisms involved in pain and behavioral alterations associated to endometriosis.
- dc.description.sponsorship “Instituto de Salud Carlos III,” “Redes temáticas de investigación cooperativa en salud—Red de trastornos adictivos” (#RD16/0017/0020), “Ministerio de Ciencia e Innovación” MICIN y “Agencia Estatal de Investigación” AEI (#PID2020-120029GBI00/MICIN/AEI/10.13039/50110001 1033), and “Generalitat de Catalunya- Agència de Gestió d’Ajuts Universitaris i de Recerca-AGAUR” (#2017-SGR-669 and #ICREA Acadèmia2020) to RM are acknowledged.
- dc.format.mimetype application/pdf
- dc.identifier.citation Escudero-Lara A, Cabañero D, Maldonado R. Contribution of CD4+ cells in the emotional alterations induced by endometriosis in mice. Front Behav Neurosci. 2022 Oct 12;16:946975. DOI: 10.3389/fnbeh.2022.946975
- dc.identifier.doi http://dx.doi.org/10.3389/fnbeh.2022.946975
- dc.identifier.issn 1662-5153
- dc.identifier.uri http://hdl.handle.net/10230/55162
- dc.language.iso eng
- dc.publisher Frontiers
- dc.relation.ispartof Front Behav Neurosci. 2022 Oct 12;16:946975
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-120029GB-I00
- dc.rights © 2022 Escudero-Lara, Cabañero and Maldonado. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword CD4
- dc.subject.keyword Anxiety
- dc.subject.keyword Chronic pelvic pain
- dc.subject.keyword Endometriosis
- dc.subject.keyword Female
- dc.subject.keyword Neuroinflammatory
- dc.title Contribution of CD4+ cells in the emotional alterations induced by endometriosis in mice
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion