Mountain gorilla genomes reveal the impact of long-term population decline and inbreeding

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• dc.contributor.author Xue, Yali
• dc.contributor.author Prado Martínez, Javier, 1987-
• dc.contributor.author de Manuel, Marc
• dc.contributor.author Hernández Rodríguez, Jéssica, 1983-
• dc.contributor.author Lobon Garcia, Irene
• dc.contributor.author Marquès i Bonet, Tomàs, 1975-
• dc.contributor.author Scally, Aylwyn
• dc.date.accessioned 2019-01-17T08:44:16Z
• dc.date.available 2019-01-17T08:44:16Z
• dc.date.issued 2015
• dc.description.abstract Mountain gorillas are an endangered great ape subspecies and a prominent focus for conservation, yet we know little about their genomic diversity and evolutionary past. We sequenced whole genomes from multiple wild individuals and compared the genomes of all four Gorilla subspecies. We found that the two eastern subspecies have experienced a prolonged population decline over the past 100,000 years, resulting in very low genetic diversity and an increased overall burden of deleterious variation. A further recent decline in the mountain gorilla population has led to extensive inbreeding, such that individuals are typically homozygous at 34% of their sequence, leading to the purging of severely deleterious recessive mutations from the population. We discuss the causes of their decline and the consequences for their future survival.
• dc.description.sponsorship Supported by Royal Society grant RG130105 (A.S.), Wellcome Trust grants 098051 (Q.A., Y.C., V.N., L.P., M.A.Q., M.S., C.T.-S., Y.X., B.Y.) and 099769/Z/12/Z (V.N.), NIH grant HG002385 (E.E.E.), a European Research Council Starting Grant (260372), and Ministerio de Ciencia e Innovacion grant BFU2011-28549 (T.M.-B.)
• dc.format.mimetype application/pdf
• dc.identifier.citation Xue Y, Prado-Martinez J, Sudmant PH, Narasimhan V, Ayub Q, Szpak M et al. Mountain gorilla genomes reveal the impact of long-term population decline and inbreeding. Science. 2015 Apr 10; 348(6231): 242-245. DOI: 10.1126/science.aaa3952
• dc.identifier.doi http://dx.doi.org/10.1126/science.aaa3952
• dc.identifier.issn 0036-8075
• dc.identifier.uri http://hdl.handle.net/10230/36307
• dc.language.iso eng
• dc.publisher American Association for the Advancement of Science (AAAS)
• dc.relation.ispartof Science. 2015 Apr 10;348(6231):242-5
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/260372
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2011-28549
• dc.rights This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science Journal Title, on Volume 348, number 6231, 2015, DOI: 10.1126/science.aaa3952
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.other Genètica
• dc.subject.other Genomes
• dc.subject.other Goril·les
• dc.subject.other Millora genètica
• dc.title Mountain gorilla genomes reveal the impact of long-term population decline and inbreeding
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion