The association between diabetes and gastric cancer: results from the Stomach Cancer Pooling Project Consortium

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Dabo, Bashir
• dc.contributor.author Kogevinas, Manolis
• dc.contributor.author Luu, Hung N.
• dc.date.accessioned 2022-06-30T06:20:36Z
• dc.date.available 2022-06-30T06:20:36Z
• dc.date.issued 2022
• dc.description.abstract Background: Prior epidemiologic studies on the association between diabetes and gastric cancer risk provided inconclusive findings, while traditional, aggregate data meta-analyses were characterized by high between-study heterogeneity. Objective: To investigate the association between type 2 diabetes and gastric cancer using data from the 'Stomach Cancer Pooling (StoP) Project', an international consortium of more than 30 case-control and nested case-control studies, which is large and provides harmonized definition of participants' characteristics across individual studies. The data have the potential to minimize between-study heterogeneity and provide greater statistical power for subgroup analysis. Methods: We included 5592 gastric cancer cases and 12 477 controls from 14 studies from Europe, Asia, North America, and South America in a two-stage individual-participant data meta-analysis. Random-effect models were used to estimate summary odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) by pooling study-specific ORs. Results: We did not find an overall association between diabetes and gastric cancer (pooled OR = 1.01, 95% CI, 0.94-1.07). However, the risk of cardia gastric cancer was significantly higher among individuals with type 2 diabetes (OR = 1.16, 95% CI, 1.02-1.33). There was no association between diabetes and gastric cancer risk in strata of Helicobacter pylori infection serostatus, age, sex, BMI, smoking status, alcohol consumption, fruit/vegetable intake, gastric cancer histologic type, and source of controls. Conclusion: This study provides additional evidence that diabetes is unrelated to gastric cancer overall but may be associated with excess cardia gastric cancer risk.
• dc.format.mimetype application/pdf
• dc.identifier.citation Dabo B, Pelucchi C, Rota M, Jain H, Bertuccio P, Bonzi R et al. The association between diabetes and gastric cancer: results from the Stomach Cancer Pooling Project Consortium. Eur J Cancer Prev. 2022 May 1;31(3):260-69. DOI: 10.1097/CEJ.0000000000000703
• dc.identifier.doi http://dx.doi.org/10.1097/CEJ.0000000000000703
• dc.identifier.issn 0959-8278
• dc.identifier.uri http://hdl.handle.net/10230/53643
• dc.language.iso eng
• dc.publisher Lippincott Williams & Wilkins
• dc.relation.ispartof Eur J Cancer Prev. 2022 May 1;31(3):260-69
• dc.rights © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBYNC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Diabetes
• dc.subject.keyword Gastric cancer
• dc.subject.keyword Risk factors
• dc.title The association between diabetes and gastric cancer: results from the Stomach Cancer Pooling Project Consortium
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion