Gut microbiota signatures of vulnerability to food addiction in mice and humans

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  • dc.contributor.author Samulenaite, Solveiga
  • dc.contributor.author García Blanco, Alejandra
  • dc.contributor.author Mayneris Perxachs, Jordi
  • dc.contributor.author Domingo Rodriguez, Laura, 1992-
  • dc.contributor.author Cabana-Domínguez, Judit
  • dc.contributor.author Fernàndez-Castillo, Noèlia
  • dc.contributor.author Gago-García, Edurne
  • dc.contributor.author Pineda-Cirera, Laura
  • dc.contributor.author Burokas, Aurelijus, 1982-
  • dc.contributor.author Espinosa-Carrasco, José
  • dc.contributor.author Arboleya, Silvia
  • dc.contributor.author Latorre, Jessica
  • dc.contributor.author Stanton, Catherine
  • dc.contributor.author Hosomi, Koji
  • dc.contributor.author Kunisawa, Jun
  • dc.contributor.author Cormand, Bru
  • dc.contributor.author Fernández Real, Jose M.
  • dc.contributor.author Maldonado, Rafael, 1961-
  • dc.contributor.author Martín García, Elena, 1975-
  • dc.date.accessioned 2024-11-18T16:17:45Z
  • dc.date.available 2024-11-18T16:17:45Z
  • dc.date.issued 2024
  • dc.description.abstract Objective: Food addiction is a multifactorial disorder characterised by a loss of control over food intake that may promote obesity and alter gut microbiota composition. We have investigated the potential involvement of the gut microbiota in the mechanisms underlying food addiction. Design: We used the Yale Food Addiction Scale (YFAS) 2.0 criteria to classify extreme food addiction in mouse and human subpopulations to identify gut microbiota signatures associated with vulnerability to this disorder. Results: Both animal and human cohorts showed important similarities in the gut microbiota signatures linked to food addiction. The signatures suggested possible non-beneficial effects of bacteria belonging to the Proteobacteria phylum and potential protective effects of Actinobacteria against the development of food addiction in both cohorts of humans and mice. A decreased relative abundance of the species Blautia wexlerae was observed in addicted humans and of Blautia genus in addicted mice. Administration of the non-digestible carbohydrates, lactulose and rhamnose, known to favour Blautia growth, led to increased relative abundance of Blautia in mice faeces in parallel with dramatic improvements in food addiction. A similar improvement was revealed after oral administration of Blautia wexlerae as a beneficial microbe. Conclusion: By understanding the crosstalk between this behavioural alteration and gut microbiota, these findings constitute a step forward to future treatments for food addiction and related eating disorders.
  • dc.description.sponsorship This work was supported by La Caixa Health #LCF/PR/HR22/52420017, the Spanish 'Ministerio de Ciencia, Innovación y Universidades (MICIU), Agencia Estatal de Investigación (AEI)' (PID2020- 120029GB-I00/MICIU/AEI/10.13039/501100011033, RD21/0009/0019), the Spanish ‘Instituto de Salud Carlos III, RETICS-RTA’ (#RD12/0028/0023), the ‘Generalitat de Catalunya, AGAUR’ (#2017 SGR-669), 'La Marató de TV3' #20221830, ‘ICREA-Acadèmia’ (#2015) and the Spanish ‘Ministerio de Sanidad, Servicios Sociales e Igualdad, ‘Plan Nacional Sobre Drogas of the Spanish Ministry of Health’ (#PNSD-2017I068) to RM, ‘Plan Nacional Sobre Drogas of the Spanish Ministry of Health’ (#PNSD-2019I006, #PNSD-2023I040) and Spanish Ministerio de Ciencia e Innovación (ERA-NET) PCI2021-122073-2A to EM-G. Spanish-MINECO (#SAF2017-84060-R-AEI/FEDER-UE) to LD-R, Spanish ‘Ministerio de Ciencia, Innovación y Universidades’ (#RTI2018-100968-B-100, #PID2021-127776OB-I00), ‘AGAUR-Generalitat de Catalunya’ (#2017-SGR-738, #2021-SGR-01093) and Spanish ‘Ministerio de Sanidad, Servicios Sociales e Igualdad, ‘Plan Nacional Sobre Drogas of the Spanish Ministry of Health’ (#PNSD-2017I050) to BC, ‘Plan Nacional Sobre Drogas of the Spanish Ministry of Health’ (#PNSD-2020I042) to NF-C and the European Regional Development Fund (project No 01.2.2-LMT-K-718-03-0099) under grant agreement with the Research Council of Lithuania (LMTLT) to AB. The research leading to these results has also received funding from the European Union H2020 Program [H2020/2014-2020] under grant agreements Nos 667302 (CoCA), 643051 (MiND) and 728018 (Eat2beNICE), 'La Marató de TV3' #20221831 and from the Catalan Government (ICREA Academia Award 2021) to BC. JC-D was supported by the H2020 CoCA and Eat2beNICE projects and EG-G by projects of the Spanish Ministries (#PNSD-2020I042 and #PID2021-127776OB-I00). This work was partially supported by Instituto de Salud Carlos III through the projects PI20/01090 and PI23/00575 to JM-P and PI18/01022 and PI21/01361 to JMF-R (co-funded by European Regional Development Fund. “A way to make Europe”). It was also supported through the project CNS2023-144218 funded by MCIN/AEI/10.13039/501100011033 and the European Union NextGenerationEU/PRTR to JM-P. The work has also received funding from ”la Caixa” Foundation under the grant agreement LCF/PR/HR22/52420017 and support from Generalitat de Catalunya (ICREA Academia Award 2021 and 2021 SGR 01263) to JMF-R. IDIBGI is a CERCA centre from the 'CERCA Programme/Generalitat de Catalunya'.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Samulenaite S, García-Blanco A, Mayneris-Perxachs J, Domingo-Rodríguez L, Cabana-Domínguez J, Fernàndez-Castillo N, et al. Gut microbiota signatures of vulnerability to food addiction in mice and humans. Gut. 2024 Oct 7;73(11):1799-815. DOI: 10.1136/gutjnl-2023-331445
  • dc.identifier.doi http://dx.doi.org/10.1136/gutjnl-2023-331445
  • dc.identifier.issn 0017-5749
  • dc.identifier.uri http://hdl.handle.net/10230/68729
  • dc.language.iso eng
  • dc.publisher BMJ Publishing Group
  • dc.relation.ispartof Gut. 2024 Oct 7;73(11):1799-815
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/667302
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-120029GB-I00
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/SAF2017-84060-R
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/RTI2018-100968-B-100
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2021-127776OB-I00
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/643051
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/728018
  • dc.rights © Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
  • dc.subject.keyword Neuropharmacology
  • dc.subject.keyword Nutrition
  • dc.subject.keyword Obesity
  • dc.subject.keyword Psychology
  • dc.title Gut microbiota signatures of vulnerability to food addiction in mice and humans
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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