Coffee consumption, genetic susceptibility and bladder cancer risk
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- dc.contributor.author Villanueva, Cristina M.
- dc.contributor.author Silverman, Debra T.
- dc.contributor.author Murta-Nascimento, Cristiane
- dc.contributor.author Malats i Riera, Núria
- dc.contributor.author García Closas, Montserrat
- dc.contributor.author Castro Domínguez, Francisco
- dc.contributor.author Tardón, Adonina
- dc.contributor.author García Closas, Reina
- dc.contributor.author Serra, Consol
- dc.contributor.author Carrato, Alfredo
- dc.contributor.author Rothman, Nathaniel
- dc.contributor.author Real, Francisco X.
- dc.contributor.author Dosemeci, Mustafa
- dc.contributor.author Kogevinas, Manolis
- dc.date.accessioned 2019-02-27T10:08:47Z
- dc.date.available 2019-02-27T10:08:47Z
- dc.date.issued 2009
- dc.description.abstract Objective: We evaluated the bladder cancer risk associated with coffee consumption in a case–control study in Spain and examined the gene–environment interactions for genetic variants of caffeine-metabolizing enzymes. Methods: The analyses included 1,136 incident cases with urothelial carcinoma of the urinary bladder and 1,138 controls. Odds ratios (OR) and 95% confidence intervals (CI) were adjusted for area, age, gender, amount of cigarette smoking, and years since quitting among former smokers. Results: The OR (95% CI) for ever consumed coffee was 1.25 (0.95–1.64). For consumers of 1, 2, 3, and 4 or more cups/day relative to never drinkers, OR were, respectively, 1.24 (0.92–1.66), 1.11 (95% CI 0.82–1.51), 1.57 (1.13–2.19), and 1.27 (0.88–1.81). Coffee consumption was higher in smokers compared to never smokers. The OR for drinking at least 4 cups/day was 1.13 (0.61–2.09) in current smokers, 1.57 (0.86–2.90) in former smokers, and 1.23 (0.55–2.76) in never smokers. Gene–coffee interactions evaluated in NAT2, CYP1A2, and CYP2E1-02 and CYP1A1 were not identified after adjusting for multiple testing. Conclusion: We observed a modest increased bladder cancer risk among coffee drinkers that may, in part, be explained by residual confounding by smoking. The findings from the gene–coffee interactions need replication in further studies.
- dc.format.mimetype application/pdf
- dc.identifier.citation Villanueva CM, Silverman DT, Murta-Nascimento C, Malats N, Garcia-Closas M, Castro F et al. Coffee consumption, genetic susceptibility and bladder cancer risk. Cancer Causes Control. 2009;20(1):121-7. DOI: 10.1007/s10552-008-9226-6
- dc.identifier.doi http://dx.doi.org/10.1007/s10552-008-9226-6
- dc.identifier.issn 0957-5243
- dc.identifier.uri http://hdl.handle.net/10230/36685
- dc.language.iso eng
- dc.publisher Springer
- dc.relation.ispartof Cancer Causes and Control. 2009;20(1):121-7
- dc.rights © Springer The final publication is available at Springer via http://dx.doi.org/10.1007/s10552-008-9226-6.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Bladder cancer
- dc.subject.keyword Coffee
- dc.subject.keyword Genetic susceptibility
- dc.subject.keyword Epidemiology
- dc.title Coffee consumption, genetic susceptibility and bladder cancer risk
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion