Therapeutic Drug Monitoring of antibiotic and antifungical drugs in paediatric and newborn patients. Consensus Guidelines of the Spanish Society of Hospital Pharmacy (SEFH) and the Spanish Society of Paediatric Infectious Diseases (SEIP)
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- dc.contributor.author Luque Pardos, Sònia
- dc.contributor.author Mendoza-Palomar, Natalia
- dc.contributor.author Aguilera-Alonso, David
- dc.contributor.author Garrido, Beatriz
- dc.contributor.author Miarons, Marta
- dc.contributor.author Piqueras, Ana Isabel
- dc.contributor.author Tévar, Enrique
- dc.contributor.author Velasco-Arnaiz, Eneritz
- dc.contributor.author Fernández-Polo, Aurora
- dc.date.accessioned 2025-10-06T06:26:08Z
- dc.date.available 2025-10-06T06:26:08Z
- dc.date.issued 2024
- dc.description.abstract Therapeutic monitoring of antibiotics and antifungals based on pharmacokinetic and pharmacodynamic (PK/PD) parameters is a strategy increasingly used for the optimization of therapy to improve efficacy, reduce the occurrence of toxicities, and prevent the selection of antimicrobial resistance, particularly in vulnerable patients including neonates and the critical or immunocompromised paediatric host. In neonates and children, infections account for a high percentage of hospital admissions, and anti-infectives are the most used drugs. However, paediatric PK/PD studies and the evidence regarding the efficacy and safety of some newly marketed antibiotics and antifungals-usually used off-label in paediatrics-to determine the optimal drug dosage regimens are limited. It is widely known that this population presents important differences in the PK parameters (especially in drug clearance and volume of distribution) in comparison with adults that may alter antimicrobial exposure and, therefore, compromise treatment success. In addition, paediatric patients are more susceptible to potential adverse drug effects and they need closer monitoring. The aim of this document, developed jointly by the Spanish Society of Hospital Pharmacy and the Spanish Society of Paediatric Infectious Diseases, is to describe the available evidence on the indications for therapeutic drug monitoring (TDM) of antibiotics and antifungals in newborn and paediatric patients, and to provide practical recommendations for TDM in routine clinical practice to optimise their dosing, efficacy and safety. Of antibiotics and antifungals in the paediatric population.
- dc.format.mimetype application/pdf
- dc.identifier.citation Luque S, Mendoza-Palomar N, Aguilera-Alonso D, Garrido B, Miarons M, Piqueras AI, et al. Therapeutic Drug Monitoring of antibiotic and antifungical drugs in paediatric and newborn patients. Consensus Guidelines of the Spanish Society of Hospital Pharmacy (SEFH) and the Spanish Society of Paediatric Infectious Diseases (SEIP). An Pediatr (Engl Ed). 2024 Sep;101(3):190-207. DOI: 10.1016/j.anpede.2024.05.001
- dc.identifier.doi http://dx.doi.org/10.1016/j.anpede.2024.05.001
- dc.identifier.issn 2341-2879
- dc.identifier.uri http://hdl.handle.net/10230/71388
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof An Pediatr (Engl Ed). 2024 Sep;101(3):190-207
- dc.rights © 2024 The Author(s). Published by Elsevier España S.L.U. on behalf of Sociedad Española de Farmacia Hospitalaria (S.E.F.H) and Asociación Española de Pediatría. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.keyword Therapeutic drug monitoring
- dc.subject.keyword Pharmacokinetics
- dc.subject.keyword Pharmacodynamics
- dc.subject.keyword Antibiotics
- dc.subject.keyword Antifungals
- dc.subject.keyword Paediatric
- dc.subject.keyword Newborn
- dc.subject.keyword Special populations
- dc.title Therapeutic Drug Monitoring of antibiotic and antifungical drugs in paediatric and newborn patients. Consensus Guidelines of the Spanish Society of Hospital Pharmacy (SEFH) and the Spanish Society of Paediatric Infectious Diseases (SEIP)
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion