Impact of oxygen delivery on the development of acute kidney injury in patients undergoing valve heart surgery

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  • dc.contributor.author Carrasco-Serrano, Elena
  • dc.contributor.author Jorge-Monjas, Pablo
  • dc.contributor.author Muñoz-Moreno, María Fé
  • dc.contributor.author Gómez-Sánchez, Esther
  • dc.contributor.author Priede-Vimbela, Juan Manuel
  • dc.contributor.author Bardají-Carrillo, Miguel
  • dc.contributor.author Cubero Gallego, Héctor
  • dc.contributor.author Tamayo Aguirre, Eduardo
  • dc.contributor.author Ortega-Loubon, Christian
  • dc.date.accessioned 2022-11-15T08:29:46Z
  • dc.date.available 2022-11-15T08:29:46Z
  • dc.date.issued 2022
  • dc.description.abstract One of the strongest risk factors for death in individuals undergoing cardiac surgery is Cardiac Surgery Associated-Acute Kidney Injury (CSA-AKI). Although the minimum kidney oxygen delivery index (DO2i) during cardiopulmonary bypass (CPB) has been reported, the optimal threshold value has not yet been established. A prospective study was conducted from June 2012 to January 2016 to asses how DO2i influences the pathogenesis of CSA-AKI, as well as its most favorable cut-off value. DO2 levels were recorded at the beginning, middle, and end of the CPB. The association between DO2i and CSA-AKI was investigated using multivariable logistic regression analysis. The optimal cut-off of DO2i as a predictor of CSA-AKI was determined using Classification and Regression Tree (CART) analysis. A total of 782 consecutive patients were enrolled. Of these, 231 (29.5%) patients developed AKI. Optimal DO2i thresholds of 303 mL/min/m2 during the CPB and 295 mL/min/m2 at the end of the intervention were identified, which increased the odds of CSA-AKI almost two-fold (Odds Ratio (OR), 1.90; 95% CI, 1.12-3.24) during the surgery and maintained that risk (OR 1.94; 95% CI, 1.15-3.29) until the end. Low DO2i during cardiopulmonary bypass is a risk factor for CSA-AKI that cannot be ruled out. Continuous renal oxygen supply monitoring for adult patients could be a promising method for predicting AKI during CPB.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Carrasco-Serrano E, Jorge-Monjas P, Muñoz-Moreno MF, Gómez-Sánchez E, Priede-Vimbela JM, Bardají-Carrillo M, et al. Impact of oxygen delivery on the development of acute kidney injury in patients undergoing valve heart surgery. J Clin Med. 2022 May 28;11(11): 3046. DOI: 10.3390/jcm11113046
  • dc.identifier.doi http://dx.doi.org/10.3390/jcm11113046
  • dc.identifier.issn 2077-0383
  • dc.identifier.uri http://hdl.handle.net/10230/54852
  • dc.language.iso eng
  • dc.publisher MDPI
  • dc.rights Copyright © 2022 by Carrasco-Serrano E, Jorge-Monjas P, Muñoz-Moreno MF, Gómez-Sánchez E, Priede-Vimbela JM, Bardají-Carrillo M, et al. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Cardiac Surgery-Associated Acute Kidney Injury
  • dc.subject.keyword Cardiopulmonary bypass
  • dc.subject.keyword Minimum kidney oxygen delivery index
  • dc.title Impact of oxygen delivery on the development of acute kidney injury in patients undergoing valve heart surgery
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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