Omega-3 fatty acid intake during pregnancy and child neuropsychological development: A Multi-Centre Population-Based Birth cohort study in Spain

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  • dc.contributor.author Tahaei, Hana
  • dc.contributor.author Gignac, Florence
  • dc.contributor.author Pinar, Ariadna
  • dc.contributor.author Fernandez-Barrés, Silvia
  • dc.contributor.author Romaguera Bosch, Dora
  • dc.contributor.author Vioque, Jesus
  • dc.contributor.author Santa Marina, Loreto
  • dc.contributor.author Subiza-Pérez, Mikel
  • dc.contributor.author Llop, Sabrina
  • dc.contributor.author Soler Blasco, Raquel
  • dc.contributor.author Arija, Victoria
  • dc.contributor.author Salas-Salvadó, Jordi
  • dc.contributor.author Tardón, Adonina
  • dc.contributor.author Riaño-Galán, Isolina
  • dc.contributor.author Sunyer Deu, Jordi
  • dc.contributor.author Guxens Junyent, Mònica
  • dc.contributor.author Júlvez Calvo, Jordi
  • dc.date.accessioned 2022-05-30T06:34:13Z
  • dc.date.available 2022-05-30T06:34:13Z
  • dc.date.issued 2022
  • dc.description.abstract Background: There are few studies that look at the intake of all types of omega-3 polyunsaturated fatty acids (n-3 PUFAs) during the different stages of pregnancy along with a long-term neuropsychological follow-up of the child. This study aims to explore the association between maternal n-3 PUFA intake during two periods of pregnancy and the child's neuropsychological scores at different ages. Methods: Prospective data were obtained for 2644 pregnant women recruited between 2004 and 2008 in population-based birth cohorts in Spain. Maternal n-3 PUFA intake during the first and third trimester of pregnancy was estimated using validated food frequency questionnaires. Child neuropsychological functions were assessed using Bayley Scales of Infant Development version one (BSID) at 1 year old, the McCarthy Scale of Children's Abilities (MSCA) at 4 years old, and the Attention Network Test (ANT) at 7 years old. Data were analysed using multivariate linear regression models and adjusted for potential covariates, such as maternal social class, education, cohort location, alcohol consumption, smoking, breastfeeding duration, and energy intake. Results: Compared to participants in the lowest quartile (<1.262 g/day) of n-3 PUFA consumption during the first trimester, those in the highest quartile (>1.657 g/day) had a 2.26 points (95% confidence interval (CI): 0.41, 4.11) higher MSCA general cognitive score, a 2.48 points (95% CI: 0.53, 4.43) higher MSCA verbal score, and a 2.06 points (95% CI: 0.166, 3.95) higher MSCA executive function score, and a 11.52 milliseconds (95% CI: -22.95, -0.09) lower ANT hit reaction time standard error. In the third pregnancy trimester, the associations were weaker. Conclusions: Positive associations between n-3 PUFA intake during early pregnancy and child neuropsychological functions at 4 and 7 years of age were found, and further clinical research is needed to confirm these findings.
  • dc.description.sponsorship This study has been funded by Instituto de Salud Carlos III through the projects “CP14/00108, PI16/00261 and PI21/00266” (co-funded by European Regional Development Fund “A way to make Europe”). Jordi Julvez and Mònica Guxens hold the Miguel Servet-II contract (CPII19/00015 and CPII18/00018, respectively) awarded by the Instituto de Salud Carlos III (co-funded by the European Social Fund “Investing in your future”). This study was also funded by grants from Instituto de Salud Carlos III (Red INMA G03/176), Generalitat de Catalunya-CIRIT 1999SGR 00241. We acknowledge support from the Spanish Ministry of Science and Innovation and the State Research Agency through the “Centro de Excelencia Severo Ochoa 2019–2023” program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA program. This study was also funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436), Generalitat de Catalunya-CIRIT 1999SGR 00241. We acknowledge support from the Spanish Ministry of Science and Innovation and the State Research Agency through the “Centro de Excelencia Severo Ochoa 2019–2023” program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA program. This study was also funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds), Generalitat de Catalunya- CIRIT 1999SGR 00241, Fundació La marató de TV3 (090430). We acknowledge support from the Spanish Ministry of Science and Innovation and the State Research Agency through the “Centro de Excelencia Severo Ochoa 2019–2023” program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA program. This study was also funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds), CIBERESP, Generalitat de Catalunya-CIRIT 1999SGR 00241, Generalitat de Catalunya-AGAUR 2009 SGR 501, Fundació La marató de TV3 (090430), EU Commission (261357). We acknowledge support from the Spanish Ministry of Science and Innovation and the State Research Agency through the “Centro de Excelencia Severo Ochoa 2019–2023” program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA program. This study was also funded by Grants from UE (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1), Spain: ISCIII (Red INMA G03/176, CB06/02/0041; FIS-FEDER: PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/1213, PI07/0314, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/2032, PI14/00891, PI14/01687, PI16/1288, and PI17/00663; Miguel Servet-FEDER CP11/00178, CP15/00025, and CPII16/00051), Generalitat Valenciana: FISABIO (UGP 15-230, UGP-15-244, and UGP-15-249), and the Alicia Koplowitz Foundation 2017. This study was also funded by grants from Instituto de Salud Carlos III (Red INMA G03/176 and CB06/02/0041), FIS-PI042018 incl. FEDER funds, FIS-PI09/02311 incl. FEDER funds, FIS-PI13/02429 incl. FEDER funds, FIS-PI18/00909 incl. FEDER funds, CIBERESP, Obra Social Cajastur/Fundación Liberbank and UNIVERSIDAD DE OVIEDO. This study was also funded by grants from Instituto de Salud Carlos III (PI06/0867 and FIS-PI18/01142 incl. FEDER funds), the Department of Health of the Basque Government (2005111093), the Provincial Government of Gipuzkoa (DFG06/002), and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain). This study was funded also by grants from Instituto de Salud Carlos III (FIS-PI09/00090 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2013111089), and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain). This study was also funded by grants from Instituto de Salud Carlos III (FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, the Department of Health of the Basque Government (2015111065), and the Provincial Government of Gipuzkoa (DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain). Jordi Salas-Salvadó is partially supported by ICREA under the ICREA Academia programme.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Tahaei H, Gignac F, Pinar A, Fernandez-Barrés S, Romaguera D, Vioque J, Santa-Marina L, Subiza-Pérez M, Llop S, Soler-Blasco R, Arija V, Salas-Salvadó J, Tardón A, Riaño-Galán I, Sunyer J, Guxens M, Julvez J. Omega-3 fatty acid intake during pregnancy and child neuropsychological development: A Multi-Centre Population-Based Birth cohort study in Spain. Nutrients. 2022 Jan 25;14(3):518. DOI: 10.3390/nu14030518
  • dc.identifier.doi http://dx.doi.org/10.3390/nu14030518
  • dc.identifier.issn 2072-6643
  • dc.identifier.uri http://hdl.handle.net/10230/53298
  • dc.language.iso eng
  • dc.publisher MDPI
  • dc.relation.ispartof Nutrients. 2022 Jan 25;14(3):518
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
  • dc.rights © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri https://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Children
  • dc.subject.keyword Maternal diet
  • dc.subject.keyword Neurodevelopment
  • dc.subject.keyword Omega-3 fatty acids
  • dc.subject.keyword Population-based cohort
  • dc.title Omega-3 fatty acid intake during pregnancy and child neuropsychological development: A Multi-Centre Population-Based Birth cohort study in Spain
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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