Flavonoids and the risk of gastric cancer: an exploratory Case-Control study in the MCC-Spain study
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- dc.contributor.author Vitelli Storelli, Facundo
- dc.contributor.author Kogevinas, Manolis
- dc.contributor.author Martín, Vicente
- dc.date.accessioned 2020-03-23T07:36:27Z
- dc.date.available 2020-03-23T07:36:27Z
- dc.date.issued 2019
- dc.description.abstract Several epidemiological studies have investigated the association between the dietary flavonoid intake and gastric cancer (GC) risk; however, the results remain inconclusive. Investigating the relationship between the different classes of flavonoids and the histological types and origin of GC can be of interest to the research community. We used data from a population-based multi-case control study (MCC-Spain) obtained from 12 different regions of Spain. 2700 controls and 329 GC cases were included in this study. Odds ratios (ORs) were calculated using the mixed effects logistic regression considering quartiles of flavonoid intakes and log2. Flavonoid intake was associated with a lower GC risk (ORlog2 = 0.76; 95% CI = 0.65-0.89; ORq4vsq1 = 0.60; 95%CI = 0.40-0.89; ptrend = 0.007). Inverse and statistically significant associations were observed with anthocyanidins, chalcones, dihydroflavonols and flavan-3-ols. The isoflavanoid intake was positively associated with higher cancer risk, but without reaching a statistical significance. In general, no differences were observed in the GC risk according to the location and histological type. The flavonoid intake seems to be a protective factor against GC within the MCC-study. This effect may vary depending on the flavonoid class but not by the histological type and location of the tumor. Broader studies with larger sample size and greater geographical variability are necessary.
- dc.format.mimetype application/pdf
- dc.identifier.citation Vitelli Storelli F, Molina AJ, Zamora-Ros R, Fernández-Villa T, Roussou V, Romaguera D, et al. Flavonoids and the risk of gastric cancer: an exploratory Case-Control study in the MCC-Spain study. Nutrients. 2019 Apr 27; 11(5). pii: E967. DOI: 10.3390/nu11050967
- dc.identifier.doi http://dx.doi.org/10.3390/nu11050967
- dc.identifier.issn 2072-6643
- dc.identifier.uri http://hdl.handle.net/10230/43981
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Nutrients. 2019 Apr 27;11(5):E967
- dc.rights © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword MCC-Spain
- dc.subject.keyword Case-control study
- dc.subject.keyword Flavonoids
- dc.subject.keyword Gastric cancer
- dc.subject.keyword Intake
- dc.title Flavonoids and the risk of gastric cancer: an exploratory Case-Control study in the MCC-Spain study
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion