Evolution of acute hepatitis C virus infection in a large European city: Trends and new patterns

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• dc.contributor.author Garriga, Césarca
• dc.contributor.author Manzanares-Laya, Sandraca
• dc.contributor.author García de Olalla, Patríciaca
• dc.contributor.author Gorrindo, Pilarca
• dc.contributor.author Lens, Sabelaca
• dc.contributor.author Solà Lamoglia, Ricardca
• dc.contributor.author Martínez-Rebollar, Maríaca
• dc.contributor.author Laguno, Montserratca
• dc.contributor.author Navarro, Jordica
• dc.contributor.author Torras, Xavierca
• dc.contributor.author Gurguí, Mercèca
• dc.contributor.author Barberà, María Jesúsca
• dc.contributor.author Quer, Josep, 1965-ca
• dc.contributor.author Masdeu, Evaca
• dc.contributor.author Simón, Pereca
• dc.contributor.author Ros, Miriamca
• dc.contributor.author Andrés, Anna deca
• dc.contributor.author Caylà i Busqueras, Joan A.ca
• dc.date.accessioned 2018-07-16T08:17:54Z
• dc.date.available 2018-07-16T08:17:54Z
• dc.date.issued 2017
• dc.description.abstract The aims of this study were to describe the evolution of acute hepatitis C virus (HCV) infections since 2004 and to determine its associated factors. Acute HCV infections diagnosed in Barcelona from 2004 to 2015 were included. Incidence ratios (IR) were then estimated for sex and age groups. Cases were grouped between 2004-2005, 2006-2011 and 2012-2015, and their incidence rate ratios (IRR) were calculated. In addition, risk factors for acute HCV infection were identified using multinomial logistic regression for complete, available and multiple imputed data. 204 new HCV cases were identified. Two peaks of higher IR of acute HCV infection in 2005 and 2013 were observed. Men and those aged 35-54 had higher IR. IRR for men was 2.9 times greater than in women (95% confidence intervals (CI): 1.8 ‒ 4.7). Factors related to the period 2012-2015 (versus 2006-2011) were: a) sexual risk factor for transmission versus nosocomial (relative-risk ratio (RRR): 13.0; 95% CI: 2.3 ‒ 72.1), b) higher educated versus lower (RRR: 5.4; 95% CI: 1.6 ‒ 18.7), and c) HIV co-infected versus not HIV-infected (RRR: 53.1; 95% CI: 5.7 ‒ 492.6). This is one of the few studies showing IR and RRRs of acute HCV infections and the first focused on a large city in Spain. Sexual risk for transmission between men, higher educational level and HIV co-infection are important factors for understanding current HCV epidemic. There has been a partial shift in the pattern of the risk factor for transmission from nosocomial to sexual.
• dc.format.mimetype application/pdf
• dc.identifier.citation Garriga C, Manzanares-Laya S, García de Olalla P, Gorrindo P, Lens S, Solà R. et al. Evolution of acute hepatitis C virus infection in a large European city: Trends and new patterns. PLoS One. 2017 Nov 14;12(11):e0187893. DOI: 10.1371/journal.pone.0187893
• dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0187893
• dc.identifier.issn 1932-6203
• dc.identifier.uri http://hdl.handle.net/10230/35163
• dc.language.iso eng
• dc.publisher Public Library of Science (PLoS)ca
• dc.relation.ispartof PLoS One. 2017 Nov 14;12(11):e0187893
• dc.rights Copyright © 2017 Garriga et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.other Hepatitis C
• dc.title Evolution of acute hepatitis C virus infection in a large European city: Trends and new patternsca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion