Outcomes of COVID-19 among hospitalized patients with non-dialysis CKD

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• dc.contributor.author Coca, Armando
• dc.contributor.author Burballa Tàrrega, Carla, 1988-
• dc.contributor.author Centellas-Pérez, Francisco Javier
• dc.contributor.author Pérez-Sáez, María José
• dc.contributor.author Bustamante-Munguira, Elena
• dc.contributor.author Ortega, Agustín
• dc.contributor.author Dueñas Gutiérrez, Carlos
• dc.contributor.author Arenas Jiménez, María Dolores
• dc.contributor.author Pérez-Martínez, Juan
• dc.contributor.author Ruiz, Guadalupe
• dc.contributor.author Crespo Barrio, Marta
• dc.contributor.author Llamas, Francisco
• dc.contributor.author Bustamante-Munguira, Juan
• dc.contributor.author Pascual Santos, Julio
• dc.date.accessioned 2021-06-30T07:44:34Z
• dc.date.available 2021-06-30T07:44:34Z
• dc.date.issued 2020
• dc.description.abstract Background: Coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome-Corona Virus 2 has generated significant impact on global health worldwide. COVID-19 can cause pneumonia and organ injury. Chronic kidney disease (CKD) has been associated with increased mortality in previous epidemics, but there is a paucity of data regarding actual risks for non-dialysis CKD patients with COVID-19. Methods: Multicenter, observational cohort study including 136 non-dialysis CKD patients and 136 age- and sex-matched controls that required hospitalization due to COVID-19. Patients with end-stage renal disease, a kidney transplant or without registered baseline glomerular filtration rate prior to COVID-19 infection were excluded. CKD and acute kidney injury (AKI) were defined according to KDIGO criteria. Results: CKD patients had higher white blood cell count and D-dimer and lower lymphocyte percentage. No differences were found regarding symptoms on admission. CKD was associated with higher rate of AKI (61 vs. 24.3%) and mortality (40.4 vs. 24.3%). Patients with AKI had the highest hazard for death (AKI/non-CKD HR:7.04, 95% CI:2.87-17.29; AKI/CKD HR:5.25, 95% CI: 2.29-12.02), followed by CKD subjects without AKI (HR:3.39, 95% CI:1.36-8.46). CKD status did not condition ICU admission or length of in-hospital stay. Conclusions: CKD patients that require hospitalization due to COVID-19 are exposed to higher risk of death and AKI.
• dc.format.mimetype application/pdf
• dc.identifier.citation Coca A, Burballa C, Centellas-Pérez FJ, Pérez-Sáez MJ, Bustamante-Munguira E, Ortega A, et al. Outcomes of COVID-19 among hospitalized patients with non-dialysis CKD. Front Med. 2020 Dec 3; 7: 615312. DOI: 10.3389/fmed.2020.615312
• dc.identifier.doi http://dx.doi.org/10.3389/fmed.2020.615312
• dc.identifier.issn 2296-858X
• dc.identifier.uri http://hdl.handle.net/10230/48012
• dc.language.iso eng
• dc.publisher Frontiers
• dc.rights Copyright © 2020 Coca, Burballa, Centellas-Pérez, Pérez-Sáez, Bustamante Munguira, Ortega, Dueñas, Arenas, Pérez-Martínez, Ruiz, Crespo, Llamas, Bustamante-Munguira and Pascual. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) http://creativecommons.org/licenses/by/4.0/. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword COVID−19
• dc.subject.keyword Acute kidney damage
• dc.subject.keyword Chornic kidney disease
• dc.subject.keyword Pneumonia
• dc.subject.keyword Renal failure
• dc.title Outcomes of COVID-19 among hospitalized patients with non-dialysis CKD
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion