Drosophila: retrotransposons making up telomeres

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• dc.contributor.author Casacuberta Suñer, Elena, 1972-
• dc.date.accessioned 2023-11-21T12:07:05Z
• dc.date.available 2023-11-21T12:07:05Z
• dc.date.issued 2017
• dc.description.abstract Drosophila and extant species are the best-studied telomerase exception. In this organism, telomere elongation is coupled with targeted retrotransposition of Healing Transposon (HeT-A) and Telomere Associated Retrotransposon (TART) with sporadic additions of Telomere Associated and HeT-A Related (TAHRE), all three specialized non-Long Terminal Repeat (non-LTR) retrotransposons. These three very special retroelements transpose in head to tail arrays, always in the same orientation at the end of the chromosomes but never in interior locations. Apparently, retrotransposon and telomerase telomeres might seem very different, but a detailed view of their mechanisms reveals similarities explaining how the loss of telomerase in a Drosophila ancestor could successfully have been replaced by the telomere retrotransposons. In this review, we will discover that although HeT-A, TART, and TAHRE are still the only examples to date where their targeted transposition is perfectly tamed into the telomere biology of Drosophila, there are other examples of retrotransposons that manage to successfully integrate inside and at the end of telomeres. Because the aim of this special issue is viral integration at telomeres, understanding the base of the telomerase exceptions will help to obtain clues on similar strategies that mobile elements and viruses could have acquired in order to ensure their survival in the host genome.
• dc.description.sponsorship This work has been supported by the Grant CGL2014-55786 to Elena Casacuberta from the Plan Nacional I+D+I. Ministerio Español de Economia y Competitividad, using FEDER funds. I also would like to thank you Josefa González and Mary-Lou Pardue for critical reading of the manuscript.
• dc.format.mimetype application/pdf
• dc.identifier.citation Casacuberta E. Drosophila: retrotransposons making up telomeres. Viruses. 2017 Jul;9(7):192. DOI: 10.3390/v9070192
• dc.identifier.doi http://dx.doi.org/10.3390/v9070192
• dc.identifier.issn 1999-4915
• dc.identifier.uri http://hdl.handle.net/10230/58346
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Viruses. 2017 Jul;9(7):192
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/CGL2014-55786
• dc.rights © 2017 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Telomere integration
• dc.subject.keyword HeT-A
• dc.subject.keyword TART
• dc.subject.keyword TAHRE
• dc.subject.keyword Drosophila
• dc.subject.keyword Telomere targeting
• dc.title Drosophila: retrotransposons making up telomeres
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion