Physical activity and lung function-Cause or consequence?

Full item page Simple item page

• dc.contributor.author Bédard, Annabelle, 1986-
• dc.contributor.author Carsin, Anne-Elie
• dc.contributor.author Fuertes, Elaine
• dc.contributor.author Accordini, Simone
• dc.contributor.author Dharmage, Shyamali C.
• dc.contributor.author Garcia Larsen, Vanessa
• dc.contributor.author Heinrich, Joachim
• dc.contributor.author Janson, Christer
• dc.contributor.author Johannessen, Ane
• dc.contributor.author Leynaert, Bénédicte
• dc.contributor.author Sánchez-Ramos, José Luis
• dc.contributor.author Peralta, Gabriela P.
• dc.contributor.author Pin, Isabelle
• dc.contributor.author Squillacioti, Giulia
• dc.contributor.author Weyler, Joost
• dc.contributor.author Jarvis, Deborah
• dc.contributor.author García Aymerich, Judith
• dc.date.accessioned 2021-01-25T07:30:56Z
• dc.date.available 2021-01-25T07:30:56Z
• dc.date.issued 2020
• dc.description.abstract Concerns exist that the positive association of physical activity with better lung function, which has been suggested in previous longitudinal studies in smokers, is due to reverse causation. To investigate this, we applied structural equation modeling (SEM), an exploratory approach, and marginal structural modeling (MSM), an approach from the causal inference framework that corrects for reverse causation and time-dependent confounding and estimates causal effects, on data from participants in the European Community Respiratory Health Survey (ECRHS, a multicentre European cohort study initiated in 1991-1993 with ECRHS I, and with two follow-ups: ECRHS II in 1999-2003, and ECRHS III in 2010-2014). 753 subjects who reported current smoking at ECRHS II, with repeated data on lung function at ECRHS I, II and III, physical activity at ECRHS II and III, and potential confounders at ECRHS I and II, were included in the analyses. SEM showed positive associations between physical activity and lung function in both directions. MSM suggested a protective causal effect of physical activity on lung function (overall difference in mean β (95% CI), comparing active versus non-active individuals: 58 mL (21-95) for forced expiratory volume in one second and 83 mL (36-130) for forced vital capacity). Our results suggest bi-directional causation and support a true protective effect of physical activity on lung function in smokers, after accounting for reverse causation and time-dependent confounding.
• dc.description.sponsorship The present analyses are part of the Ageing Lungs in European Cohorts (ALEC) Study (www.alecstudy.org), which has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement no 633212.
• dc.format.mimetype application/pdf
• dc.identifier.citation Bédard A, Carsin AE, Fuertes E, Accordini S, Dharmage SC, Garcia-Larsen V, Heinrich J, Janson C, Johannessen A, Leynaert B, Sánchez-Ramos JL, Peralta GP, Pin I, Squillacioti G, Weyler J, Jarvis D, Garcia-Aymerich J. Physical activity and lung function-Cause or consequence? PLoS One. 2020; 15(8):e0237769. DOI: 10.1371/journal.pone.0237769
• dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0237769
• dc.identifier.issn 1932-6203
• dc.identifier.uri http://hdl.handle.net/10230/46259
• dc.language.iso eng
• dc.publisher Public Library of Science (PLoS)
• dc.relation.ispartof PLoS One. 2020; 15(8):e0237769
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/633212
• dc.rights © 2020 Bédard et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Physical activity
• dc.subject.keyword Pulmonary function
• dc.subject.keyword Body weight
• dc.subject.keyword Diet
• dc.subject.keyword Respiratory infections
• dc.subject.keyword Data management
• dc.subject.keyword Nutrition
• dc.subject.keyword Longitudinal studies
• dc.title Physical activity and lung function-Cause or consequence?
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion