Triple negative breast cancer subtypes and pathologic complete response rate to neoadjuvant chemotherapy
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- dc.contributor.author Santonja, Angela
- dc.contributor.author Albanell Mestres, Joan
- dc.contributor.author Alba, Emilio
- dc.date.accessioned 2019-07-04T06:26:32Z
- dc.date.available 2019-07-04T06:26:32Z
- dc.date.issued 2018
- dc.description.abstract Triple negative breast cancer (TNBC) is a heterogeneous disease with distinct molecular subtypes that differentially respond to chemotherapy and targeted agents. The purpose of this study is to explore the clinical relevance of Lehmann TNBC subtypes by identifying any differences in response to neoadjuvant chemotherapy among them. We determined Lehmann subtypes by gene expression profiling in paraffined pre-treatment tumor biopsies from 125 TNBC patients treated with neoadjuvant anthracyclines and/or taxanes +/- carboplatin. We explored the clinicopathological characteristics of Lehmann subtypes and their association with the pathologic complete response (pCR) to different treatments. The global pCR rate was 37%, and it was unevenly distributed within Lehmann's subtypes. Basal-like 1 (BL1) tumors exhibited the highest pCR to carboplatin containing regimens (80% vs 23%, p=0.027) and were the most proliferative (Ki-67>50% of 88.2% vs. 63.7%, p=0.02). Luminal-androgen receptor (LAR) patients achieved the lowest pCR to all treatments (14.3% vs 42.7%, p=0.045 when excluding mesenchymal stem-like (MSL) samples) and were the group with the lowest proliferation (Ki-67≤50% of 71% vs 27%, p=0.002). In our cohort, only tumors with LAR phenotype presented non-basal-like intrinsic subtypes (HER2-enriched and luminal A). TNBC patients present tumors with a high genetic diversity ranging from highly proliferative tumors, likely responsive to platinum-based therapies, to a subset of chemoresistant tumors with low proliferation and luminal characteristics.
- dc.description.sponsorship This work was supported by Centro de Investigación Biomédica en Red de Cáncer (CIBERONC) from Instituto de Salud Carlos III (ISCIII) (CB16/12/00241, CB16/12/00471, CB16/12/00481) and by research grants from ISCIII (PI13/00730), Mutua Madrileña 2013 and Sociedad Española de Oncología Médica (SEOM) 2013. The authors acknowledge support through grant TIN2017-88728-C2-1-R from MICINN-SPAIN. Angela Santonja has a predoctoral grant PFIS-ISCIII (FI12/00489).
- dc.format.mimetype application/pdf
- dc.identifier.citation Santonja A, Sánchez-Muñoz A, Lluch A, Chica-Parrado MR, Albanell J, Chacón JI. Et al. Triple negative breast cancer subtypes and pathologic complete response rate to neoadjuvant chemotherapy. Oncotarget. 2018 May 29;9(41):26406-26416. DOI: 10.18632/oncotarget.25413
- dc.identifier.doi http://dx.doi.org/10.18632/oncotarget.25413
- dc.identifier.issn 1949-2553
- dc.identifier.uri http://hdl.handle.net/10230/41927
- dc.language.iso eng
- dc.publisher Impact Journal
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/TIN2017-88728-C2-1-R
- dc.rights Copyright : © 2018 Santonja et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), https://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri https://creativecommons.org/licenses/by/3.0/
- dc.subject.keyword Carboplatin
- dc.subject.keyword Neoadjuvant therapy
- dc.subject.keyword Pathologic complete response
- dc.subject.keyword Subtyping
- dc.subject.keyword Triple negative breast cancer
- dc.title Triple negative breast cancer subtypes and pathologic complete response rate to neoadjuvant chemotherapy
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion