Metabolic signatures associated with severity in hospitalized COVID-19 patients
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- dc.contributor.author Marín Corral, Judith
- dc.contributor.author Rodríguez-Morató, Jose, 1987-
- dc.contributor.author Gómez-Gómez, Àlex
- dc.contributor.author Pascual Guàrdia, Sergi, 1979-
- dc.contributor.author Muñoz-Bermúdez, Rosana
- dc.contributor.author Salazar Degracia, Anna
- dc.contributor.author Pérez-Terán, Purificación
- dc.contributor.author Restrepo, Marcos I.
- dc.contributor.author Khymenets, Olha, 1974-
- dc.contributor.author Haro, Noemí
- dc.contributor.author Masclans Enviz, Joan Ramon
- dc.contributor.author Pozo Mendoza, Óscar J., 1975-
- dc.date.accessioned 2021-09-23T06:32:14Z
- dc.date.available 2021-09-23T06:32:14Z
- dc.date.issued 2021
- dc.description.abstract The clinical evolution of COVID-19 pneumonia is poorly understood. Identifying the metabolic pathways that are altered early with viral infection and their association with disease severity is crucial to understand COVID-19 pathophysiology, and guide clinical decisions. This study aimed at assessing the critical metabolic pathways altered with disease severity in hospitalized COVID-19 patients. Forty-nine hospitalized patients with COVID-19 pneumonia were enrolled in a prospective, observational, single-center study in Barcelona, Spain. Demographic, clinical, and analytical data at admission were registered. Plasma samples were collected within the first 48 h following hospitalization. Patients were stratified based on the severity of their evolution as moderate (N = 13), severe (N = 10), or critical (N = 26). A panel of 221 biomarkers was measured by targeted metabolomics in order to evaluate metabolic changes associated with subsequent disease severity. Our results show that obesity, respiratory rate, blood pressure, and oxygen saturation, as well as some analytical parameters and radiological findings, were all associated with disease severity. Additionally, ceramide metabolism, tryptophan degradation, and reductions in several metabolic reactions involving nicotinamide adenine nucleotide (NAD) at inclusion were significantly associated with respiratory severity and correlated with inflammation. In summary, assessment of the metabolomic profile of COVID-19 patients could assist in disease severity stratification and even in guiding clinical decisions.
- dc.format.mimetype application/pdf
- dc.identifier.citation Marín-Corral J, Rodríguez-Morató J, Gomez-Gomez A, Pascual-Guardia S, Muñoz-Bermúdez R, Salazar-Degracia A, Pérez-Terán P, Restrepo MI, Khymenets O, Haro N, Masclans JR, Pozo OJ. Metabolic signatures associated with severity in hospitalized COVID-19 patients. Int J Mol Sci. 2021;22(9):4794. DOI: 10.3390/ijms22094794
- dc.identifier.doi http://dx.doi.org/10.3390/ijms22094794
- dc.identifier.issn 1422-0067
- dc.identifier.uri http://hdl.handle.net/10230/48493
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Int J Mol Sci. 2021;22(9):4794
- dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword COVID-19
- dc.subject.keyword Ceramides
- dc.subject.keyword Kynurenine
- dc.subject.keyword Metabolomics
- dc.subject.keyword Severity
- dc.title Metabolic signatures associated with severity in hospitalized COVID-19 patients
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion