Dynamics of phenotypic heterogeneity associated with EMT and stemness during cancer progression
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- dc.contributor.author Jolly, Mohit Kumar
- dc.contributor.author Celià-Terrassa, Toni
- dc.date.accessioned 2020-02-10T08:22:22Z
- dc.date.available 2020-02-10T08:22:22Z
- dc.date.issued 2019
- dc.description.abstract Genetic and phenotypic heterogeneity contribute to the generation of diverse tumor cell populations, thus enhancing cancer aggressiveness and therapy resistance. Compared to genetic heterogeneity, a consequence of mutational events, phenotypic heterogeneity arises from dynamic, reversible cell state transitions in response to varying intracellular/extracellular signals. Such phenotypic plasticity enables rapid adaptive responses to various stressful conditions and can have a strong impact on cancer progression. Herein, we have reviewed relevant literature on mechanisms associated with dynamic phenotypic changes and cellular plasticity, such as epithelial-mesenchymal transition (EMT) and cancer stemness, which have been reported to facilitate cancer metastasis. We also discuss how non-cell-autonomous mechanisms such as cell-cell communication can lead to an emergent population-level response in tumors. The molecular mechanisms underlying the complexity of tumor systems are crucial for comprehending cancer progression, and may provide new avenues for designing therapeutic strategies.
- dc.format.mimetype application/pdf
- dc.identifier.citation Jolly MK, Celià-Terrassa A. Dynamics of phenotypic heterogeneity associated with EMT and stemness during cancer progression. J Clin Med. 2019 Sep 25;8(10):1542. DOI: 10.3390/jcm8101542
- dc.identifier.doi http://dx.doi.org/10.3390/jcm8101542
- dc.identifier.issn 2077-0383
- dc.identifier.uri http://hdl.handle.net/10230/43532
- dc.language.iso eng
- dc.publisher MDPI
- dc.rights Copyright © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Cancer stem cells
- dc.subject.keyword Cell plasticity
- dc.subject.keyword Cellular dynamics
- dc.subject.keyword Epithelial-to-mesenchymal transition
- dc.subject.keyword Mathematical modeling
- dc.subject.keyword Population homeostasis
- dc.title Dynamics of phenotypic heterogeneity associated with EMT and stemness during cancer progression
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion