Toward male individualization with rapidly mutating y-chromosomal short tandem repeats

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• dc.contributor.author Ballantyne, Kaye N.ca
• dc.contributor.author Comas, David, 1969-ca
• dc.contributor.author Sanz, Paulaca
• dc.contributor.author Kayser, Manfredca
• dc.date.accessioned 2017-02-10T08:08:03Z
• dc.date.available 2017-02-10T08:08:03Z
• dc.date.issued 2014ca
• dc.description.abstract Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used for testing close paternal relationships among individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strikingly, >99% of the 12,272 unrelated males were completely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99836-0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% nonunique haplotypes), significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). Analysis of molecular variance revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 father-son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RM Y-STRs in identifying and separating unrelated and related males and provides a reference database.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Ballantyne KN, Ralf A, Aboukhalid R, Achakzai NM, Anjos MJ, Ayub Q et al. Toward male individualization with rapidly mutating y-chromosomal short tandem repeats. Hum Mutat. 2014 Aug; 35(8): 1021-32. DOI: 10.1002/humu.22599ca
• dc.identifier.doi http://dx.doi.org/10.1002/humu.22599
• dc.identifier.issn 1059-7794ca
• dc.identifier.uri http://hdl.handle.net/10230/28106
• dc.language.iso engca
• dc.publisher Wileyca
• dc.relation.ispartof Human Mutation. 2014 Aug;35(8):1021-32
• dc.rights © 2014, Kaye N. Ballantyne et al. ∗∗Human Mutation published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly citedca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri https://creativecommons.org/licenses/by/3.0/
• dc.subject.other Cromosoma Y
• dc.subject.other Genètica de poblacions humanes
• dc.subject.other Ressenya genètica
• dc.title Toward male individualization with rapidly mutating y-chromosomal short tandem repeatsca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca