Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons drives overconsumption of palatable food and obesity

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• dc.contributor.author Ruiz de Azua, Iñigo
• dc.contributor.author Martín García, Elena, 1975-
• dc.contributor.author Domingo Rodriguez, Laura, 1992-
• dc.contributor.author Aparisi Rey, Alejandro
• dc.contributor.author Pascual Cuadrado, Diego
• dc.contributor.author Islami, Larglinda
• dc.contributor.author Turunen, Petri
• dc.contributor.author Remmers, Floortje
• dc.contributor.author Lutz, Beat
• dc.contributor.author Maldonado, Rafael, 1961-
• dc.date.accessioned 2021-03-11T07:09:29Z
• dc.date.available 2021-03-11T07:09:29Z
• dc.date.issued 2021
• dc.description.abstract Palatable food can promote overfeeding beyond homeostatic requirements, thereby constituting a major risk to obesity. Here, the lack of cannabinoid type 1 receptor (CB1) in dorsal telencephalic glutamatergic neurons (Glu-CB1-KO) abrogated the overconsumption of palatable food and the development of obesity. On low-fat diet, no genotype differences were observed. However, under palatable food conditions, Glu-CB1-KO mice showed decreased body weight and food intake. Notably, Glu-CB1-KO mice were protected from alterations in the reward system after high-fat diet feeding. Interestingly, obese wild-type mice showed a superior olfactory detection as compared to mutant mice, suggesting a link between overconsumption of palatable food and olfactory function. Reconstitution of CB1 expression in olfactory cortex in high-fat diet-fed Glu-CB1-KO mice using viral gene delivery partially reversed the lean phenotype concomitantly with improved odor perception. These findings indicate that CB1 in cortical glutamatergic neurons regulates hedonic feeding, whereby a critical role of the olfactory cortex was uncovered as an underlying mechanism.
• dc.format.mimetype application/pdf
• dc.identifier.citation Ruiz de Azua I, Martin-Garcia E, Domingo-Rodriguez L, Aparisi Rey A, Pascual Cuadrado D, Islami L, Turunen P, Remmers F, Lutz B, Maldonado R. Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons drives overconsumption of palatable food and obesity. Neuropsychopharmacology. 2021 Feb 8;46:982-91. DOI: 10.1038/s41386-021-00957-z
• dc.identifier.doi http://dx.doi.org/10.1038/s41386-021-00957-z
• dc.identifier.issn 0893-133X
• dc.identifier.uri http://hdl.handle.net/10230/46722
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Neuropsychopharmacology. 2021 Feb 8;46:982-91
• dc.rights © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Obesity
• dc.subject.keyword Reward
• dc.title Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons drives overconsumption of palatable food and obesity
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion