Adipose tissue protects against hepatic steatosis in male rats fed a high-fat diet plus liquid fructose: Sex-related differences

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• dc.contributor.author Bentanachs, Roger
• dc.contributor.author Blanco, Laia
• dc.contributor.author Montesinos, Maria
• dc.contributor.author Sala Vila, Aleix
• dc.contributor.author Lázaro, Iolanda
• dc.contributor.author Rodríguez-Morató, Jose, 1987-
• dc.contributor.author Sánchez, Rosa María
• dc.contributor.author Laguna, Juan Carlos
• dc.contributor.author Roglans i Ribas, Núria
• dc.contributor.author Alegret i Jordà, Marta
• dc.date.accessioned 2024-05-29T06:16:08Z
• dc.date.available 2024-05-29T06:16:08Z
• dc.date.issued 2023
• dc.description.abstract Non-alcoholic fatty liver disease is a sexual dimorphic disease, with adipose tissue playing an essential role. Our previous work showed that female rats fed a high-fat high-fructose diet devoid of cholesterol (HFHFr) developed simple hepatic steatosis dissociated from obesity. This study assessed the impact of the HFHFr diet on the male rat metabolism compared with data obtained for female rats. A total of 16 Sprague Dawley (SD) male rats were fed either a control (standard rodent chow and water) or HFHFr (high-fat diet devoid of cholesterol, plus 10% fructose in drinking water) diet for 3 months. Unlike female rats, and despite similar increases in energy consumption, HFHFr males showed increased adiposity and hyperleptinemia. The expression of hormone-sensitive lipase in the subcutaneous white adipose tissue was enhanced, leading to high free fatty acid and glycerol serum levels. HFHFr males presented hypertriglyceridemia, but not hepatic steatosis, partially due to enhanced liver PPARα-related fatty acid β-oxidation and the VLDL-promoting effect of leptin. In conclusion, the SD rats showed a sex-related dimorphic response to the HFHFr diet. Contrary to previous results for HFHFr female rats, the male rats were able to expand the adipose tissue, increase fatty acid catabolism, or export it as VLDL, avoiding liver lipid deposition.
• dc.description.sponsorship This research was funded by the following grants: SAF2017-82369-R, funded by MCIN/AEI/10.13039/501100011033/ and FEDER, “A Way of Making Europe”; PID2020-112870RB-I00, funded by MCIN/AEI/10.13039/501100011033/; and 2021SGR-00345, funded by Generalitat de Catalunya. R.B. is a predoctoral fellow, funded by PREDOCS-UB from the University of Barcelona.
• dc.format.mimetype application/pdf
• dc.identifier.citation Bentanachs R, Blanco L, Montesinos M, Sala-Vila A, Lázaro I, Rodríguez-Morató J, et al. Adipose tissue protects against hepatic steatosis in male rats fed a high-fat diet plus liquid fructose: Sex-related differences. Nutrients. 2023 Sep 8;15(18):3909. DOI: 10.3390/nu15183909
• dc.identifier.doi http://dx.doi.org/10.3390/nu15183909
• dc.identifier.issn 2072-6643
• dc.identifier.uri http://hdl.handle.net/10230/60277
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Nutrients. 2023 Sep 8;15(18):3909
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/SAF2017-82369-R
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-112870RB-I00
• dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Adipose tissue
• dc.subject.keyword Fructose
• dc.subject.keyword High-fat diet
• dc.subject.keyword Leptin
• dc.subject.keyword Non-esterified fatty acids
• dc.title Adipose tissue protects against hepatic steatosis in male rats fed a high-fat diet plus liquid fructose: Sex-related differences
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion