Seafood consumption, omega-3 fatty acids intake, and life-time prevalence of depression in the PREDIMED-Plus trial

Mostra el registre complet Registre parcial de l'ítem

  • dc.contributor.author Sánchez Villegas, Almudena
  • dc.contributor.author Zomeño Fajardo, Maria Dolores
  • dc.contributor.author Fitó Colomer, Montserrat
  • dc.date.accessioned 2019-06-25T07:44:47Z
  • dc.date.available 2019-06-25T07:44:47Z
  • dc.date.issued 2018
  • dc.description.abstract BACKGROUND: The aim of this analysis was to ascertain the type of relationship between fish and seafood consumption, omega-3 polyunsaturated fatty acids (ω-3 PUFA) intake, and depression prevalence. METHODS: Cross-sectional analyses of the PREDIMED-Plus trial. Fish and seafood consumption and ω-3 PUFA intake were assessed through a validated food-frequency questionnaire. Self-reported life-time medical diagnosis of depression or use of antidepressants was considered as outcome. Depressive symptoms were collected by the Beck Depression Inventory-II. Logistic regression models were used to estimate the association between seafood products and ω-3 PUFA consumption and depression. Multiple linear regression models were fitted to assess the association between fish and long-chain (LC) ω-3 PUFA intake and depressive symptoms. RESULTS: Out of 6587 participants, there were 1367 cases of depression. Total seafood consumption was not associated with depression. The odds ratios (ORs) (95% confidence intervals (CIs)) for the 2nd, 3rd, and 4th quintiles of consumption of fatty fish were 0.77 (0.63⁻0.94), 0.71 (0.58⁻0.87), and 0.78 (0.64⁻0.96), respectively, and p for trend = 0.759. Moderate intake of total LC ω-3 PUFA (approximately 0.5⁻1 g/day) was significantly associated with a lower prevalence of depression. CONCLUSION: In our study, moderate fish and LC ω-3 PUFA intake, but not high intake, was associated with lower odds of depression suggesting a U-shaped relationship.
  • dc.description.sponsorship This research was funded by the Spanish Ministry of Health (Carlos III Health Institute) through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (grant numbers and corresponding codes: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14-00696, PI14/01206, PI14/01919, PI14/00853), the European Research Council (Advanced Research Grant 2013–2018; 340918) grant to MAMG, the Recercaixa grant to J. S-S. and NB (2013ACUP00194), the grant from the Consejería de Salud de la Junta de Andalucía (PI0458/2013; PS0358/2016), the SEMERGEN grant, and FEDER funds (CB06/03).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Sánchez-Villegas A, Álvarez-Pérez J, Toledo E, Salas-Salvadó J, Ortega-Azorín C, Zomeño MD. Et al. Seafood consumption, omega-3 fatty acids intake, and life-time prevalence of depression in the PREDIMED-Plus trial. Nutrients. 2018 Dec 18;10(12). pii: E2000. DOI: 10.3390/nu10122000
  • dc.identifier.doi http://dx.doi.org/10.3390/nu10122000
  • dc.identifier.issn 2072-6643
  • dc.identifier.uri http://hdl.handle.net/10230/41860
  • dc.language.iso eng
  • dc.publisher MDPI
  • dc.relation.ispartof Nutrients. 2018 Dec 18;10(12):E2000
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/340918
  • dc.rights Copyright © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Depression
  • dc.subject.keyword Docosahexaenoic acid
  • dc.subject.keyword Eicosapentaenoic acid
  • dc.subject.keyword Fish
  • dc.subject.keyword Omega-3
  • dc.title Seafood consumption, omega-3 fatty acids intake, and life-time prevalence of depression in the PREDIMED-Plus trial
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Hospital del Mar Research Institute)
Documents OpenAIRE (Open Access Infrastructure for Research in Europe)