Functions and dysfunctions of nitric oxide in brain

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• dc.contributor.author Picón-Pagès, Pol
• dc.contributor.author Garcia Buendia, Joan
• dc.contributor.author Muñoz López, Francisco José, 1964-
• dc.date.accessioned 2020-07-03T06:46:47Z
• dc.date.available 2020-07-03T06:46:47Z
• dc.date.issued 2019
• dc.description.abstract Nitric oxide (NO) works as a retrograde neurotransmitter in synapses, allows the brain blood flow and also has important roles in intracellular signaling in neurons from the regulation of the neuronal metabolic status to the dendritic spine growth. Moreover NO is able to perform post-translational modifications in proteins by the S-nitrosylation of the thiol amino acids, which is a physiological mechanism to regulate protein function. On the other hand, during aging and pathological processes the behavior of NO can turn harmful when reacts with superoxide anion to form peroxynitrite. This gaseous compound can diffuse easily throughout the neuronal membranes damaging lipid, proteins and nucleic acids. In the case of proteins, peroxynitrite reacts mostly with the phenolic ring of the tyrosines forming nitro-tyrosines that affects dramatically to the physiological functions of the proteins. Protein nitrotyrosination is an irreversible process that also yields to the accumulation of the modified proteins contributing to the onset and progression of neurodegenerative processes such as Alzheimer's disease or Parkinson's disease.
• dc.description.sponsorship This work was supported by the Spanish Ministry of Economy and Business through the grant Plan Estatal SAF2017-83372-R (FEDER funds/UE) and MDM-2014-0370 through the “María de Maeztu” Programme for Units of Excellence in R&D to “Departament de Ciències Experimentals i de la Salut”.
• dc.format.mimetype application/pdf
• dc.identifier.citation Picón-Pagès P, Garcia-Buendia J, Muñoz FJ. Functions and dysfunctions of nitric oxide in brain. Biochim Biophys Acta Mol Basis Dis. 2019; 1865(8):1949-67. DOI: 10.1016/j.bbadis.2018.11.007
• dc.identifier.doi http://dx.doi.org/10.1016/j.bbadis.2018.11.007
• dc.identifier.issn 0925-4439
• dc.identifier.uri http://hdl.handle.net/10230/45065
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Biochim Biophys Acta Mol Basis Dis. 2019; 1865(8):1949-67
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/SAF2017-83372-R
• dc.rights © 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/)
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/BY/4.0/
• dc.subject.keyword Alzheimer's disease
• dc.subject.keyword Glutamatergic signaling
• dc.subject.keyword Nitric oxide
• dc.subject.keyword Nitrosylation
• dc.subject.keyword Nitrotyrosine
• dc.subject.keyword Peroxynitrite
• dc.title Functions and dysfunctions of nitric oxide in brain
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion